GENOME-RELATED DATASETS WITHIN THE ESCHERICHIA-COLI GENETIC STOCK CENTER DATABASE
GENOME-RELATED DATASETS WITHIN THE ESCHERICHIA-COLI GENETIC STOCK CENTER DATABASE
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DOI：
10.1093/nar/20.23.6143
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发表时间：
1992-12-11
影响因子：
14.9
通讯作者：
LETOVSKY, S
中科院分区：
文献类型：
--
作者：
BERLYN, MB;LETOVSKY, S
介绍了大肠杆菌遗传储备中心数据库的内容以及与序列数据库最相关的信息子集的电子形式的可用性。该数据库使用长期的库存中心记录（由B. J. Bachmann博士开发和管理）描述大肠杆菌K-12突变衍生物的基因型，包括等位基因、结构突变、交配型和质粒以及菌株的来源、名称和起源以及参考文献。该数据库包括突变、突变特性、基因、基因特性和基因产物的描述，以及酶的EC编号标识符。不包括序列信息，但条目是指测序区域的序列数据库登录号。一个基因被描述为一个更一般的染色体间隔类别的亚型，称为位点。由于位点用于描述任何染色体间隔，因此作图信息与位点相关联。等位基因被描述为这些位点的突变，它们不是主要的地图对象，但从相应的位点描述继承地图位置信息。数据库设计旨在保留已知细节的丰富性和测量或信息的不确定性，以便尽可能准确地表示库存中心记录。
The contents of the E.coli Genetic Stock Center database and the availability in electronic form of the subset of information most relevant to sequence databases are described. The database uses the long-standing Stock Center records (developed and curated by Dr B.J.Bachmann) in describing genotypes of mutant derivatives of E.coli K-12 in terms of alleles, structural mutations, mating type, and plasmids as well as the derivation, names and originators of the strain, and references. The database includes descriptions of mutations, mutation properties, genes, gene properties, and gene products, with EC number identifiers for enzymes. Sequence information is not included, but entries refer to sequence database accession numbers for sequenced regions. A gene is described as a subtype of a more general category of chromosome interval called Site. Since sites are used to describe any chromosomal interval, mapping information is associated with sites. Alleles are described as mutations of those sites and they are not primary map objects, but inherit map position information from the corresponding site description. The database design is intended to preserve richness of detail where it is known and uncertainty of measurements or information as it occurs in order to represent the stock center records as accurately as possible.