Altered brain white matter structural motor network in spinocerebellar ataxia type 3.
Altered brain white matter structural motor network in spinocerebellar ataxia type 3.
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DOI：
10.1002/acn3.51713
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发表时间：
2023-03
影响因子：
5.3
通讯作者：
Chen, Qun-Lin
中科院分区：
文献类型：
--
作者：
Chen, Xin-Yuan;Huang, Zi-Qiang;Lin, Wei;Li, Meng-Cheng;Ye, Zhi-Xian;Qiu, Yu-Sen;Xia, Xiao-Yue;Chen, Na-Ping;Hu, Jian-Ping;Gan, Shi-Rui;Chen, Qun-Lin
脊髓小脑共济失调3型是一种脑网络内的疾病。然而，大脑网络与疾病严重程度之间的关系仍不清楚。本研究旨在探讨白色物质（WM）结构运动网络的变化，在临床前和共济失调阶段，及其与疾病严重程度的关系。在这项研究中，招募了20名共济失调患者、20名临床前SCA 3患者和20名健康对照，并接受MRI扫描。使用SARA和ICARS评分量化疾病严重程度。WM电机结构网络使用概率纤维跟踪创建，并使用图论和基于网络的统计在全局，节点和边缘水平进行分析。此外，分析网络拓扑测量与疾病持续时间或临床评分之间的相关性。临床前患者表现出运动网络的重复性增加，改变的子网络包括11个节点的12条边，5个脑区表现出节点强度降低。在共济失调患者的运动网络的重复性也增加，但全球效率，全球的力量，和传递性下降。共济失调患者表现出更广泛的改变子网和更多的减少节点的强度。运动网络的传递性与SARA和ICARS评分呈负相关。SCA 3的WM运动网络的变化在共济失调发作之前就开始了，并且WM运动网络的参与随着疾病的进展而增加。WM运动网络的全球网络拓扑测量似乎是疾病严重程度的一个有前途的图像生物标志物。这项研究为SCA 3/MJD疾病的病理生理学提供了新的见解。
Spinocerebellar ataxia type 3 is a disorder within the brain network. However, the relationship between the brain network and disease severity is still unclear. This study aims to investigate changes in the white matter (WM) structural motor network, both in preclinical and ataxic stages, and its relationship with disease severity. For this study, 20 ataxic, 20 preclinical SCA3 patients, and 20 healthy controls were recruited and received MRI scans. Disease severity was quantified using the SARA and ICARS scores. The WM motor structural network was created using probabilistic fiber tracking and was analyzed using graph theory and network‐based statistics at global, nodal, and edge levels. In addition, the correlations between network topological measures and disease duration or clinical scores were analyzed. Preclinical patients showed increasing assortativity of the motor network, altered subnetwork including 12 edges of 11 nodes, and 5 brain regions presenting reduced nodal strength. In ataxic patients assortativity of the motor network also increased, but global efficiency, global strength, and transitivity decreased. Ataxic patients showed a wider altered subnetwork and a higher number of reduced nodal strengths. A negative correlation between the transitivity of the motor network and SARA and ICARS scores was observed in ataxic patients. Changes to the WM motor network in SCA3 start before ataxia onset, and WM motor network involvement increases with disease progression. Global network topological measures of the WM motor network appear to be a promising image biomarker for disease severity. This study provides new insights into the pathophysiology of disease in SCA3/MJD.
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