PRIMARY STRUCTURE AND FUNCTIONAL EXPRESSION FROM COMPLEMENTARY-DNA OF A HUMAN INTERLEUKIN-1 RECEPTOR ANTAGONIST
PRIMARY STRUCTURE AND FUNCTIONAL EXPRESSION FROM COMPLEMENTARY-DNA OF A HUMAN INTERLEUKIN-1 RECEPTOR ANTAGONIST
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DOI：
10.1038/343341a0
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发表时间：
1990-01-25
期刊：
影响因子：
64.8
通讯作者：
THOMPSON, RC
中科院分区：
文献类型：
--
作者：
EISENBERG, SP;EVANS, RJ;THOMPSON, RC
粘附IgG诱导的人单核细胞分泌一种白细胞介素-1受体拮抗剂，这可能对白细胞介素-1活性的体内调节很重要。该分子的互补DNA已从人类单核细胞文库中分离出来。单核细胞RNA分析表明该基因受转录调控。受体拮抗剂的序列表明它在结构上与IL-lp相似。cDNA在大肠杆菌IL-1受体拮抗剂活性中的表达。
Human monocytes induced with adherent IgG secrete an interleukin-1 receptor antagonist which could be important for thein vivoregulation of IL-1 activity. A complementary DNA for this molecule has been isolated from a human monocyte library. Analysis of monocyte RNA indicates that the gene is transcriptionally regulated. The sequence of the receptor antagonist indicates that it is structurally similar to IL-lp. Expression of the cDNA inEscherichia coliyields IL-1 receptor antagonist activity.