Improvement of nutritional measures during preoperative parenteral nutrition in patients selected by the prognostic nutritional index: a randomized controlled trial.
Improvement of nutritional measures during preoperative parenteral nutrition in patients selected by the prognostic nutritional index: a randomized controlled trial.
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按预后营养指数选择的患者术前肠外营养期间营养措施的改善：一项随机对照试验。
DOI：
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发表时间：
1988
期刊：
影响因子：
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通讯作者：
R. Hartemink
中科院分区：
文献类型：
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作者：
R. Smith;R. Hartemink
接受大型胃肠道手术的患者预后营养指数(PNI)评分大于30%的患者被随机分为两组，一组接受术前10天的静脉营养，另一组在下一次方便的手术列表上接受手术。两组17名患者在年龄、性别和营养状况上非常匹配。虽然他们接受了不同的手术，但程度相似：12+/-3天的肠外营养导致体重增加，3.2+/-2.3 kg p<0.01；增加三头肌皮褶，0.6+/-1.2 mm p<0.05；改善免疫状态，p<0.02；改善PNI，5.5+/-10.1%p<0.05。血清白蛋白、转铁蛋白变化不明显。治疗组仅发生3例严重并发症，1例死亡，与对照组6例严重并发症，3例死亡相比，差异无显着性。这项研究表明，需要进行大型胃肠道手术的明显营养衰竭的患者将从术前肠外营养疗程中受益，但要最终证明这一点，还需要一项大规模的、可能是多中心的研究。
Patients undergoing major gastrointestinal surgery who had a prognostic nutritional index (PNI) score of greater than 30% were randomized to receive a preoperative course of 10 days of intravenous nutrition or to undergo surgery at the next convenient operation list. Two groups of 17 patients were well matched for age, sex, and nutritional status. Although they underwent diverse operations, the extent of these was similar: 12 +/- 3 days of parenteral nutrition resulted in weight gain, 3.2 +/- 2.3 kg p less than 0.01; increased triceps skinfold, 0.6 +/- 1.2 mm p less than 0.05; improved immunological state, p less than 0.02; and improved PNI, 5.5 +/- 10.1% p less than 0.05. The changes in serum albumin and transferrin were not significant. There were only three major complications with one death in the treatment group but this was not significantly different from the control group which had six major complications and three deaths. This study suggests that patients with demonstrable nutritional depletion who require major gastrointestinal surgery will benefit from a preoperative course of parenteral nutrition, but to conclusively prove this a large and probably multicentre study will be required.