B Vitamin and/or ω-3 Fatty Acid Supplementation and Cancer Ancillary Findings From the Supplementation With Folate, Vitamins B6 and B12, and/or Omega-3 Fatty Acids (SU.FOL.OM3) Randomized Trial
B Vitamin and/or ω-3 Fatty Acid Supplementation and Cancer Ancillary Findings From the Supplementation With Folate, Vitamins B6 and B12, and/or Omega-3 Fatty Acids (SU.FOL.OM3) Randomized Trial
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DOI：
10.1001/archinternmed.2011.1450
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发表时间：
2012-04-09
影响因子：
--
通讯作者：
Hercberg, Serge
中科院分区：
文献类型：
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作者：
Andreeva, Valentina A.;Touvier, Mathilde;Hercberg, Serge
背景：为了进一步了解单个营养素的癌症化学预防潜力，我们研究了维生素B和/或omega-3脂肪酸补充剂对心血管疾病幸存者癌症结局的影响。方法：这是补充叶酸、维生素B-6和B-12和/或Omega-3脂肪酸（su . folo . om3）二级预防试验（2003-2009）的辅助研究。共有2501名年龄在45至80岁之间的个体被随机分为以下4个每日补充组：(1)5-甲基四氢叶酸（0.56 mg）、盐酸吡哆醇（维生素B-6, 3 mg）和氰钴胺素（维生素B-12, 0.02 mg）；(2)二十碳五烯酸和二十二碳六烯酸（600毫克）按2:1的比例配制；(3) B族维生素和omega-3脂肪酸；或(4)安慰剂。使用Cox比例风险模型估计癌症结局的总体风险比（hr）和性别特异性风险比（95% cl）。结果：在补充5年后，7.0%的样本（男性145例，女性29例）发生了癌症事件，2.3%的样本发生了癌症死亡。癌症结局与补充B族维生素（HR, 1.15 [95% CI, 0.85-1.55]）和/或omega-3脂肪酸（HR, 1.17 [95% CI, 0.87-1.58]）之间没有关联。不同性别的治疗之间存在统计学上显著的相互作用，补充omega-3脂肪酸对男性的癌症风险没有影响，而增加了女性的癌症风险（HR, 3.02 [95% CI, 1.33-6.89]）。结论：我们发现补充相对低剂量的B族维生素和/或omega-3脂肪酸对既往心血管疾病患者的癌症结局没有有益影响。
Background: To advance knowledge about the cancer-chemopreventive potential of individual nutrients, we investigated the effects of B vitamin and/or omega-3 fatty acid supplements on cancer outcomes among survivors of cardiovascular disease.Methods: This was an ancillary study of the Supplementation With Folate, Vitamins B-6 and B-12 and/or Omega-3 Fatty Acids (SU.FOL.OM3) secondary prevention trial (2003-2009). In all, 2501 individuals aged 45 to 80 years were randomized in a 2 x 2 factorial design to one of the following 4 daily supplementation groups: (1) 5-methyltetrahydrofolate (0.56 mg), pyridoxine hydrochloride (vitamin B-6;3 mg) and cyanocobalamin (vitamin B-12;0.02 mg); (2) eicosapentaenoic and docosahexaenoic acid (600 mg) in a 2: 1 ratio; (3) B vitamins and omega-3 fatty acids; or (4) placebo. Overall and sex-specific hazard ratios (HRs) and 95% Cls regarding the cancer outcomes were estimated with Cox proportional hazards models.Results: After 5 years of supplementation, incident cancer was validated in 7.0% of the sample (145 events in men and 29 in women), and death from cancer occurred in 2.3% of the sample. There was no association between cancer outcomes and supplementation with B vitamins (HR, 1.15 [95% CI, 0.85-1.55]) and/or omega-3 fatty acids (HR, 1.17 [95% CI, 0.87-1.58]). There was a statistically significant interaction of treatment by sex, with no effect of treatment on cancer risk among men and increased cancer risk among women for omega-3 fatty acid supplementation (HR, 3.02 [95% CI, 1.33-6.89]).Conclusion: We found no beneficial effects of supplementation with relatively low doses of B vitamins and/ or omega-3 fatty acids on cancer outcomes in individuals with prior cardiovascular disease.