PRELIMINARY-STUDY OF THE FREQUENCY OF BENIGN PROSTATIC HYPERPLASIA AND PROSTATIC-CANCER IN CHINA
PRELIMINARY-STUDY OF THE FREQUENCY OF BENIGN PROSTATIC HYPERPLASIA AND PROSTATIC-CANCER IN CHINA
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DOI：
10.1016/s0090-4295(94)80207-6
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发表时间：
1994-11-01
期刊：
影响因子：
2.1
通讯作者：
KONG, XT
中科院分区：
文献类型：
--
作者：
GU, FL;XIA, TL;KONG, XT
目的了解中国前列腺良性增生（BPH）和前列腺癌（CaP）的发病情况。从1989年至1992年收集了321例非选择性尸检的前列腺标本。从先端到基部每隔0.5 cm垂直切片。每个前列腺取5 ~ 12片切片。标本采用苏木精-伊红和马松三色染色，60例完整前列腺膀胱切除术标本测定潜伏性cap的发生频率。按年龄分，前列腺增生的发生频率为：41 ~ 50岁，13.2%；51 - 60岁，20%；61 - 70岁，50%；71 ~ 80岁，占57.1%；81 - 90岁，83.3%。潜伏性CaP的发病频率按年龄划分如下：41 ~ 50岁，2.2%；51 - 60岁，9.3%；61 ~ 70岁，5.9%；70岁以上，25%。676例BPH手术标本中有33例（4.9%）发现偶发CaP。1985年至1987年，北京市CaP发病率和死亡率分别为2.41 / 10万和1.19 / 10万。本世纪初，前列腺增生在中国很少见，但近几十年来已成为一种常见病。中国BPH的组织学频率与西方国家相似，但潜伏性CaP的组织学频率不到西方国家的一半。中国CaP的发病率和死亡率比西方国家低20倍左右。中国男性的组织学CaP不像西方男性那样可能演变为临床CaP。
Objectives This study determined the frequency of benign prostatic hyperplasia (BPH) and cancer of the prostate (CaP) in China.Methods. Prostate specimens from 321 unselected autopsies were collected from 1989 to 1992. Slices were cut vertically every 0.5 cm from apex to base. Five to 12 slices were obtained from each prostate. Specimens were stained with hematoxylin-eosin and Masson trichrome, Sixty surgical specimens obtained from cystoprostatectomies with intact prostate were included to determine the frequency of latent CaP.Results. The frequency of BPH, by age, was as follows: 41 to 50 years, 13.2%; 51 to 60 years, 20%; 61 to 70 years, 50%; 71 to 80 years, 57.1%; 81 to 90 years, 83.3%. The frequency of latent CaP, by age, was as follows: 41 to 50 years, 2.2%; 51 to 60 years, 9.3%; 61 to 70 years, 5.9%; 70 years or older, 25%. Incidental CaP was found in 4.9% (33 of 676) of BPH surgical specimens. The incidence of and mortality from CaP in Beijing were 2.41 per 100,000 men and 1.19 per 100,000 men, respectively, between 1985 and 1987.Conclusions. BPH was rare in China in the early years of this century, but it has become a common disease in recent decades. The histologic frequency of BPH in China was similar to that in Western countries, but the histologic frequency of latent CaP was less than half that in Western countries. The incidence of and mortality from CaP in China are about 20 times less than those in Western countries. Histologic CaP in a Chinese man is not as likely to evolve into clinical CaP as in a Western man.