PARKINSONS-DISEASE IN 65 PAIRS OF TWINS AND IN A SET OF QUADRUPLETS
PARKINSONS-DISEASE IN 65 PAIRS OF TWINS AND IN A SET OF QUADRUPLETS
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DOI：
10.1212/wnl.33.7.815
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发表时间：
1983-01-01
期刊：
影响因子：
9.9
通讯作者：
CALNE, DB
中科院分区：
文献类型：
--
作者：
WARD, CD;DUVOISIN, RC;CALNE, DB
在43对单合子(MZ)和19对杂合子(DZ)中，1例确诊为帕金森S病(PD)，只有1对MZ明确符合帕金森病。如果包括临床特征可疑的对，48对MZ和19对DZ中有1对是一致的。在指示病例与PD的同卵双生子中，PD的频率与年龄和性别匹配的无关对照组的预期频率相似。尽管无法确定单一环境因素，但PD病因的主要因素似乎是非遗传的。
Among 43 monozygotic (MZ) and 19 dizygotic (DZ) pairs in which an index case had definite Parkinson''s disease (PD), only 1 MZ pair was definitely concordant for PD. When pairs with questionable clinical features were included, 4 of 48 MZ and 1 of 19 DZ pairs were concordant. The frequency of PD in MZ cotwins of index cases with PD was similar to that expected in an unrelated control group matched for age and sex. Although a single environmental agent could not be identified, the major factors in the etiology of PD seem nongenetic.