Studies on preparation of 2-Acetylbenzimidazole
Studies on preparation of 2-Acetylbenzimidazole
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2-乙酰苯并咪唑的制备研究
DOI：
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发表时间：
2012
期刊：
影响因子：
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通讯作者：
P. K. Dubey
中科院分区：
文献类型：
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作者：
P. Kumar;P. K. Dubey
邻苯二胺（1）与乳酸（2）在Philips条件下缩合得到2-（α-羟乙基）苯并咪唑（3）。在稀盐酸中用K_2Cr_2O_7氧化3。用文献方法合成了2-乙酰基苯并咪唑（4）。已经尝试了几种方法，使用各种氧化剂/沉淀剂来优化从3制备4。
o-Phenylenediamine (1) was condensed with lactic acid (2) under Philips conditions to obtain the previously known 2-(α-hydroxyethyl)benzimidazole (3). Oxidation of 3 with K2Cr2O7 in dil. H2SO4 using the literature method gave the previously reported 2-acetylbenzimidazole (4). Several methods have been tried using various oxidising agents / dehydrogenating agents to optimise the preparation of 4 from 3.