HISTAMINE-RECEPTORS ON RABBIT BLASTOCYST AND ENDOMETRIAL CELL-MEMBRANES
HISTAMINE-RECEPTORS ON RABBIT BLASTOCYST AND ENDOMETRIAL CELL-MEMBRANES
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DOI：
10.1038/278648a0
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发表时间：
1979-01-01
期刊：
影响因子：
64.8
通讯作者：
ABDOU, NI
中科院分区：
文献类型：
--
作者：
DEY, SK;VILLANUEVA, C;ABDOU, NI
DESPITE much study, the role of histamine in ovum implantation remains unclear1–5. Histamine action is mediated by H1and H2receptors6,7, which are widely distributed on the cell membranes of mammalian tissues8–14. However, no information is available about the histamine receptors on blastocyst or endometrial cell membranes. Recent evidence indicates that a certain lymphocyte subpopulation carries histamine receptors9and has an important regulatory functionin vitro10–12andin vivo12,13in mice9–11, guinea pigs12and man13. Murine T cells, capable of regulating antibody secretionin vitro10, and precursors of T cells, capable of mediating cytotoxic effector cells11, carry histamine receptors. The density of these receptors increases with cell maturation11. Cell activation by histamine results in increased levels of intracellular cyclic AMP11and production of small molecular weight material, called histamine suppressor factor, capable of suppressing both cell proliferation and lymphokine production by sensitised lymphocytes following exposure to the antigen12. Histamine suppression of delayed hypersensitivity in guinea pigsin vivocan be blocked completely or partially by H2and H1antagonists, respectively12. Also, the administration of H2antagonists to man results in enhancement of delayed skin tests13. These observations indicate that lymphocytes carrying H2receptors acquire immunosuppressor potential on activation.
