Association between Neuron-Specific Enolase Gene Polymorphism and Delayed Encephalopathy after Acute Carbon Monoxide Poisoning.
Association between Neuron-Specific Enolase Gene Polymorphism and Delayed Encephalopathy after Acute Carbon Monoxide Poisoning.
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神经元特异性烯醇化酶基因多态性与急性一氧化碳中毒后迟发性脑病的相关性
DOI：
10.1155/2020/8819210
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发表时间：
2020
影响因子：
2.8
通讯作者：
Gu R
中科院分区：
文献类型：
--
作者：
Xu L;Liu X;Zhao J;Zeng J;Gu J;Zhang X;Zhang F;Han Y;Li W;Zhang P;Gu R
The aim of this study is to explore the relationship between neuron-specific enolase (NSE) gene polymorphism and delayed encephalopathy after acute carbon monoxide poisoning (DEACMP) and provide a theoretical basis for DEACMP pathogenesis, diagnosis, and prognosis. To investigate this relationship, we screened 6 NSE single nucleotide polymorphisms (SNPs), based on the results of the previous genome-wide association studies (GWAS). A total of 1,201 patients, including 416 in the DEACMP group and 785 in the acute carbon monoxide poisoning (ACMP) group, were detected by the Sequenom MassARRAY® method. The genotype frequencies and alleles of the 6 NSE SNPs (rs2071074, rs2071417, rs2071419, rs11064464, rs11064465, and rs3213434) were compared using different genetic models. In the SNPs rs2071419 and rs3213434, we found that the genotypes and allele frequencies in the two groups significantly correlated with the grouping of patients (χ2 = 6.596, p = 0.037; χ2 = 8.769, p = 0.012). The haplotypes GGTTTC and CCTTTC of ACMP and DEACMP were different (χ2 = 6.563, p = 0.010; χ2 = 4.151, p = 0.042). We also observed that rs2071419 and rs3213434 significantly correlated with DEACMP-increased risk in the dominant, codominant, and overdominant genetic models. In addition, we speculated that the C allele of the rs2071419 polymorphism and the T allele of the rs3213434 polymorphism in NSE may increase the DEACMP risk (p = 0.011, p = 0.006). The results show that rs2071419 and rs3213434 are susceptible sites of DEACMP. The NSE C allele of rs2071419 and T allele of rs3213434 and the haplotypes GGTTTC and CCTTTC may be risk factors for DEACMP.
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影响因子：
2.8
作者：
Cha, Y. S.;Kim, H.;Hwang, S. O.
通讯作者：
Hwang, S. O.
影响因子：
3.8
作者：
THOM, SR
通讯作者：
THOM, SR
通过 GWAS 分析和 Sequenom MassARRAY(R) 验证，鉴定出 LRCH1 多态性与急性一氧化碳中毒后迟发性脑病相关。
影响因子：
--
作者：
Gu, Jiapeng;Zeng, Jiao;Gu, Renjun
通讯作者：
Gu, Renjun
DOI：
10.1016/s1006-706x(06)60084-8
发表时间：
2006-09-01
影响因子：
2.5
作者：
Jiao Zhi-jie;Hu Xian-lei;Wang Guo-dong
通讯作者：
Wang Guo-dong
影响因子：
3.7
作者：
Smith HM;Smith BP;Morales NB;Moskwa S;Clingeleffer PR;Thomas MR
通讯作者：
Thomas MR