Correlation Between gp96 Expression and the Surgical Outcome in Patients With Esophageal Squamous Cell Carcinoma
Correlation Between gp96 Expression and the Surgical Outcome in Patients With Esophageal Squamous Cell Carcinoma
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DOI：
10.1245/s10434-010-1128-7
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发表时间：
2011-03-01
影响因子：
3.7
通讯作者：
Yusup, Gulbostan
中科院分区：
文献类型：
--
作者：
Akutsu, Yasunori;Matsubara, Hisahiro;Yusup, Gulbostan
热休克蛋白gp 96在抗肿瘤免疫反应中起重要作用。Gp 96与抗肿瘤免疫密切相关。本研究采用免疫组化方法检测了78例食管鳞癌患者gp 96蛋白的表达，并分析了gp 96蛋白表达与食管鳞癌患者预后的关系。采用单因素（logrank检验）和多因素（考克斯比例风险回归法）分析临床病理因素与患者生存的关系，其中gp 96阳性57例（73%），阴性21例（27%）。gp 96阴性患者的生存期（5年生存期，22.9个月）明显短于gp 96阳性患者（45.8个月; P = 0.049），多因素分析显示，gp 96阴性是生存不良的独立危险因素（风险比，2.577; P = 0.040）。gp 96阴性组的淋巴结转移率高于阴性组，尤其是T1期组（gp 96阴性组4.8vs.gp96阳性组0.84; P = 0.064）。
Heat-shock protein gp96 plays an important role in antitumor immunoreactions. Gp96 has a close relationship with antitumor immunity. This study evaluated the correlation between gp96 expression and the prognosis in esophageal squamous cell carcinoma.Seventy-eight patients with primarily resected esophageal squamous cell carcinoma were enrolled onto this study, and gp96 expression was evaluated by immunohistochemical staining. The association of clinicopathological factors and patients' survival was calculated by univariate (log rank test) and multivariate (Cox proportional hazard regression method) analyses.Fifty-seven (73%) of 78 cases were gp96 positive, and 21 were negative (27%). The survival of patients with gp96-negative disease was significantly shorter (5-year survival, 22.9 months) than with gp96-positive disease (45.8 months; P = 0.049), and the multivariate analysis showed that gp96 negativity is an independent risk factor for poor survival (hazard ratio, 2.577; P = 0.040). Gp96-negative cases had more metastatic lymph nodes than did negative cases, especially in T1 cases (4.8 in gp96-negative cases vs. 0.84 in gp96-positive cases; P = 0.064)The downregulation of gp96 expression is closely correlated with poor survival in esophageal squamous cell carcinoma.