Biodegradable intramedullary nail (BIN) with high-strength bioceramics for bone fracture
Biodegradable intramedullary nail (BIN) with high-strength bioceramics for bone fracture
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用于骨折的高强度生物陶瓷可生物降解髓内钉（BIN）
DOI：
10.1039/d0tb02423f
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发表时间：
2021
影响因子：
7
通讯作者：
Wang Huiming
中科院分区：
文献类型：
--
作者：
Sun Miao;Shao Huifeng;Xu Haibin;Yang Xiaofu;Dong Mingyi;Gong Jiaxing;Yu Mengfei;Gou Zhongru;He Yong;Liu An;Wang Huiming
全世界每年发生约1000万例骨折，其中60%以上为长骨骨折。一般认为，髓内钉在骨折刚性固定中具有显著的优势。金属髓内钉（IN）可以提供强大的支持，但在临床上可能会出现应力遮挡效应，导致骨不连愈合。不可降解的金属也需要通过第二次手术去除。INs是否可以生物降解并用于解决这一问题？由于目前可降解的生物材料总是遭受低强度，不能用于Ins，在这里，我们报告了一种新的装置组成的可生物降解的IN（BIN）首次与生物陶瓷。这些BIN具有极高的弯曲强度和稳定的内部和外部结构。实验表明，BINS不仅可以固定和支撑胫骨骨折模型，而且可以促进成骨，影响骨髓腔微环境。因此，它们有望取代传统的金属内固定，成为胫骨骨折更有效的治疗选择。
About 10 million fractures occur worldwide each year, of which more than 60% are long bone fractures. It is generally agreed that intramedullary nails have significant advantages in rigid fracture fixation. Metal intramedullary nails (INs) can provide strong support but a stress shielding effect can occur that results in nonunion healing in clinic. Nondegradable metals also need to be removed by a second operation. Could INs be biodegradable and used to overcome this issue? As current degradable biomaterials always suffer from low strength and cannot be used in Ins, herein, we report a novel device consisting of biodegradable IN (BIN) made for the first time with bioceramics. These BINs have an extremely high bending strength and stable internal and external structure. Experiments show that the BINs could not only fix and support the tibial fracture model, but also promote osteogenesis and affect the microenvironment of the bone marrow cavity. Therefore, they could be expected to replace traditional metal IN and become a more effective treatment option for tibial fractures.