Molecular links between aging and adipose tissue
Molecular links between aging and adipose tissue
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DOI：
10.1038/sj.ijo.0802912
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发表时间：
2005-03-01
影响因子：
4.9
通讯作者：
Guarente, L
中科院分区：
文献类型：
--
作者：
Picard, F;Guarente, L
白色脂肪组织现在成为控制寿命的关键器官。到目前为止，卡路里限制延长了所有生物体的寿命，主要影响脂肪组织中的能量储存。旨在改变脂肪质量的基因操作也会影响几种模式生物的寿命。我们最近提出了沉默信息调节因子2(Sir2)的同源基因sirtuin 1(SIRT1)，它是酵母基因Sir2的哺乳动物同源基因，参与了将寿命与脂肪组织联系起来的分子机制。SIRT1抑制过氧化物酶体增殖物激活受体γ的反式激活，并抑制脂肪细胞中的脂质积累。脂肪组织减少对寿命的影响可能是由于作用于大脑等靶组织的脂肪因子的产生，或者是由于间接预防与年龄相关的代谢疾病，如2型糖尿病或动脉粥样硬化。
White adipose tissue now emerges as a pivotal organ controlling lifespan. Calorie restriction, which so far extends lifespan in all organisms, primarily affects energy stores in adipose tissue. Genetic manipulations aiming at modifying fat mass also impact on the duration of life in several model organisms. We recently proposed that silent information regulator 2 (SIR2) ortholog, sirtuin 1 (SIRT1), the mammalian ortholog of the life-extending yeast gene SIR2, is involved in the molecular mechanisms linking lifespan to adipose tissue. SIRT1 represses peroxisome proliferator-activated receptors gamma transactivation and inhibits lipid accumulation in adipocytes. The effect of adipose tissue reduction on lifespan could be due to the production of adipokines acting on target tissues such as the brain, or due to the indirect prevention of age-related metabolic disorders like type 2 diabetes or atherosclerosis.