Transforming growth factor beta production during rat cytomegalovirus infection
Transforming growth factor beta production during rat cytomegalovirus infection
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DOI：
10.1099/0022-1317-78-1-205
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发表时间：
1997-01-01
影响因子：
3.8
通讯作者：
Schijns, VECJ
中科院分区：
文献类型：
--
作者：
Haagmans, BL;Teerds, KJ;Schijns, VECJ
我们分析了在大鼠模型系统中巨细胞病毒（CMV）感染期间转化生长因子β（TGF-β）的产生。感染大鼠巨细胞病毒（RCMV）的免疫活性大鼠的脾细胞释放的TGF-β增加（1）。TGF-β的产生在RCMV感染的放射免疫抑制大鼠中也很明显;它们的血清抑制了白细胞介素2诱导的T细胞增殖，抗TGF-β抗体可以恢复这种增殖。此外，TGF-β的产生可以在放射免疫抑制感染大鼠的肺、脾、肝和骨髓中进行免疫组织学观察。病毒直接诱导这种细胞因子，因为在体外RCMV感染时产生TGF-β。诱导TGF-β产生可能有助于CMV感染期间的免疫抑制。
We analysed the production of transforming growth factor beta (TGF-beta) during a cytomegalovirus (CMV) infection in a rat model system. Splenocytes from immunocompetent rats infected with rat CMV (RCMV) released increased amounts of TGF-beta(1). TGF-beta production was also evident in RCMV-infected radiation-immunosuppressed rats; their sera inhibited the interleukin 2-induced proliferation of T cells, which could be restored by anti-TGF-beta antibodies. In addition, TGF-beta production could be visualized immunohistologically in the lungs, spleen, liver and bone marrow of radiation-immunosuppressed infected rats. The virus directly induced this cytokine since TGF-beta was produced upon RCMV infection in vitro. The induction of TGF-beta production may contribute to immunosuppression during CMV infection.