Loss, restoration, and maintenance of plasma membrane integrity.
Loss, restoration, and maintenance of plasma membrane integrity.
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DOI：
10.1083/jcb.137.1.1
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发表时间：
1997-04-07
影响因子：
7.8
通讯作者：
Steinhardt, RA
中科院分区：
文献类型：
--
作者：
McNeil, PL;Steinhardt, RA
质膜完整性的破坏必然损害该结构作为屏障的基本作用，这可以杀死受影响的细胞。然而，动物细胞质膜，不受细胞壁的保护，非常容易受到机械诱导的破坏。此外，许多组织环境产生并接收“生理”水平的机械力，其对组成细胞施加剪切、拉伸和压缩应力。我们在这里检查导致膜破坏的组织条件和细胞用于防止破坏诱导的死亡和快速恢复膜完整性的机制。机械应力也会引起细胞的适应性反应，细胞必须感知并响应这种刺激。例如，骨骼肌在其寿命期间经历高度可变的机械负荷。它的单个肌纤维必须适应这种变化的机械环境，响应于增加的负荷而肥大，响应于减少的负荷而萎缩。组织结构的这种变化是重要的，因为它们改善了机械功能，经济地利用了宝贵的资源，修复或替换了受损的组件，和/或防止了未来的损伤。我们在这里简要回顾了已知的质膜破坏在转导细胞对机械负荷的反应中的作用。
Abreak in the integrity of the plasma membrane im-mediately compromises this structure’s essential role as a barrier, and this can kill the affected cell. Yet animal cell plasma membranes, unprotected by a cell wall, are highly vulnerable to mechanically induced disruption. Moreover, many tissue environments generate and receive “physiological” levels of mechanical force that impose shear, tensile, and compressive stresses on constituent cells. We examine here the tissue conditions that lead to membrane disruptions and the mechanisms that cells use for preventing disruption-induced death and for rapidly restoring membrane integrity. Mechanical stress also induces an adaptive response by cells, which must sense and respond to this stimulus. A skeletal muscle, for example, experiences during its lifetime a highly variable degree of mechanical load. Its individual myofibers must adapt to this changing mechanical environment, hypertrophying in response to increased load and atrophying in response to decreased load. Such changes in tissue architecture are important because they improve mechanical functioning, make economical use of valuable resources, repair or replace injured components, and/or prevent future injury. We here review briefly what is known about the role of plasma membrane disruption in transducing cell responses to mechanical load.
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DOI：
10.1016/0005-2736(90)90135-b
发表时间：
1990-04-30
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子：
--
作者：
FISHMAN, HM;TEWARI, KP;STEIN, PG
通讯作者：
STEIN, PG
影响因子：
37.8
作者：
Cheng, GC;Libby, P;Lee, RT
通讯作者：
Lee, RT
影响因子：
7.8
作者：
MCNEIL, PL;MUTHUKRISHNAN, L;DAMORE, PA
通讯作者：
DAMORE, PA
影响因子：
10.5
作者：
CHAN, YM;ANTONLAMPRECHT, I;FUCHS, E
通讯作者：
FUCHS, E
DOI：
10.1016/0005-2736(77)90269-3
发表时间：
1977-01-01
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子：
--
作者：
BILLAH, MM;FINEAN, JB;MICHELL, RH
通讯作者：
MICHELL, RH