INFLUENCE OF RUNNING WHEEL ACTIVITY ON FREE-RUNNING SLEEP WAKE AND DRINKING CIRCADIAN-RHYTHMS IN MICE
INFLUENCE OF RUNNING WHEEL ACTIVITY ON FREE-RUNNING SLEEP WAKE AND DRINKING CIRCADIAN-RHYTHMS IN MICE
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DOI：
10.1016/0031-9384(91)90080-8
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发表时间：
1991-08-01
影响因子：
2.9
通讯作者：
DEMENT, WC
中科院分区：
文献类型：
--
作者：
EDGAR, DM;KILDUFF, TS;DEMENT, WC
先前的研究表明，活动水平的操纵可以改变睡眠/觉醒和活动节律的特征。 通过同时测量饮水和睡眠/觉醒节律来评估这些观察结果的一般性，同时小鼠在恒定条件（DD）下自由或无法获得转轮。 在“无轮”（无限制）条件下观察到所有参数的强大昼夜节律。 当轮子被锁定时，睡眠/清醒昼夜节律的峰值幅度降低了约50%，而不影响饮酒节律的幅度。 当轮子被锁定时，随着NREM和REM睡眠的增加，每个昼夜的总清醒时间减少了11%。 而饮酒波形的振幅不受影响，轮限制导致两种节奏的周期长度（τ）的相等增加。 这些结果表明，与活动对tau蛋白的广义影响不同，活动限制对节律振幅的影响并不适用于所有行为和/或生理变量。 这项工作也支持这样的观点，即活动对睡眠/觉醒节律振幅的影响反映了行为的“掩蔽”，而不是生物钟直接耦合机制的根本变化。
Previous studies have indicated that manipulation of activity levels can modify characteristics of sleep/wake and activity rhythms. The generality of these observations was evaluated by simultaneously measuring drinking and sleep/wake rhythms while mice had free or no access to a running wheel in constant conditions (DD). Robust circadian rhythms in all parameters were observed in the "wheel free" (unrestricted) condition. When wheels were locked, the peak amplitude of the sleep/wake circadian rhythm decreased by approximately 50% without affecting the amplitude of the drinking rhythm. Total wake time decreased 11% per circadian day when wheels were locked with increases in both NREM and REM sleep. Whereas the amplitude of the drinking waveform was unaffected, wheel restriction caused an equivalent increase in period length (tau) for both rhythms. These results indicate that, unlike the generalized effects of activity on tau, activity restriction influences on rhythm amplitude do not generalize to all behavioral and/or physiological variables. This work also supports the notion that activity influences on sleep/wake rhythm amplitude reflect behavioral "masking" rather than a fundamental change in the direct coupling mechanisms of the biological clock.