Radiogenomics: Creating a link between molecular diagnostics and diagnostic imaging
Radiogenomics: Creating a link between molecular diagnostics and diagnostic imaging
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DOI：
10.1016/j.ejrad.2009.01.050
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发表时间：
2009-05-01
影响因子：
3.3
通讯作者：
Kuo, Michael D.
中科院分区：
文献类型：
--
作者：
Rutman, Aaron M.;Kuo, Michael D.
采用高通量生物学技术的研究最近有助于改进人类癌症的特征，允许新的亚分类，更好的诊断准确性和更精确的预测。然而，除其他事项外，手术获取组织的要求限制了此类方法在日常患者护理中的临床应用。放射成像在临床实践中是常规的，但目前是基于组织病理学的。常规放射成像的使用提供了一个潜在的平台，将特定的成像特征与特定的基因表达模式联系起来，从而告知潜在的细胞病理生理；然后，成像特征可以作为分子替代品，有助于各种形式的人类癌症的诊断、预后和可能的基因表达相关治疗反应。这篇综述的重点是高通量方法，如基因表达的微阵列分析，它们在癌症研究中的作用，特别是将基因表达模式与放射成像表型相关联的新方法，称为“放射基因组学”。这些发现强调了诊断和介入放射科医生在通过放射成像研究对癌症患者进行遗传评估方面的潜在未来作用。2009爱思唯尔爱尔兰有限公司版权所有。
Studies employing high-throughput biological techniques have recently contributed to an improved characterization of human cancers, allowing for novel sub-classification, better diagnostic accuracy, and more precise prognostication. However, requirement of surgical procurement of tissue among other things limits the clinical application of such methods in everyday patient care. Radiographic imaging is routine in clinical practice but is currently histopathology based. The use of routine radiographic imaging provides a potential platform for linking specific imaging traits with specific gene expression patterns that inform the underlying cellular pathophysiology; imaging features could then serve as molecular surrogates that contribute to the diagnosis, prognosis, and likely gene-expression-associated treatment response of various forms of human cancer. This review focuses on high-throughput methods such as microarray analysis of gene expression, their role in cancer research, and in particular, on novel methods of associating gene expression patterns with radiographic imaging phenotypes, known as "radiogenomics." These findings underline a potential future role of both diagnostic and interventional radiologists in genetic assessment of cancer patients with radiographic imaging studies. (C) 2009 Elsevier Ireland Ltd. All rights reserved.