HORMONAL RISK-FACTORS IN TESTICULAR CANCER - A CASE-CONTROL STUDY
HORMONAL RISK-FACTORS IN TESTICULAR CANCER - A CASE-CONTROL STUDY
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DOI：
10.1093/oxfordjournals.aje.a114369
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发表时间：
1986-07-01
影响因子：
5
通讯作者：
GURGIN, V
中科院分区：
文献类型：
--
作者：
MOSS, AR;OSMOND, D;GURGIN, V
作者采访了273名在1976年至1981年间被诊断为40岁及以下的北加州睾丸癌患者，以及他们的母亲，并在产前激素暴露和其他变量方面匹配同龄人对照和他们的母亲。纳入了一项以人群为基础的子研究（1979-1981），纳入了旧金山湾区监测、流行病学和最终结果登记处报告的所有可访谈病例。他们发现，与隐睾症相关的比值比（OR）从8.3（儿子报告）到4.5（母亲报告），但与母亲在怀孕期间的激素暴露或己烯雌酚暴露无关。他们还发现，较低的青春期年龄与抑郁有显著关联（OR = 2.0）；与母亲患乳腺癌有显著相关性（OR = 2.9, p = 0.054）；单核细胞增多症有显著的保护作用（OR = 0.6）。在以人群为基础的亚研究中，这些关联仍然很强。当病例按组织学划分时，发现青春期提前（OR = 2.3）和母亲乳腺癌（OR = 4.4）与非半精细胞瘤癌，以及已报告的单核细胞增多症（OR = 0.3）与半精细胞瘤癌有很强的特异性关联。这些观察结果表明，1)产前外源性激素暴露并不能解释睾丸癌的显著部分，2)一组“乳腺癌样”危险因素与非精原细胞瘤有关，3)非精原细胞瘤存在一些遗传风险。
The authors interviewed 273 northern California testicular cancer cases aged 40 and under diagnosed between 1976 and 1981, their mothers, and matched peer controls and their mothers on prenatal hormone exposure and other variables. Included was a population-based substudy (1979-1981) of all interviewable cases reported to the San Francisco Bay Area Surveillance, Epidemiology, and End Results registry. They found odds ratios (OR) of from 8.3 (sons'' report) to 4.5 (mothers'' report) associated with cryptorchidism, but found no association with mothers'' hormone exposure or diethylstilbestrol exposure in pregnancy. They also found a significant association with lower age at puberty (OR = 2.0); a marginally significant association with mothers'' breast cancer (OR = 2.9, p = 0.054); and a significant protective effect of reported mononucleosis (OR = 0.6). These associations remained strong in the population-based substudy. When cases were divided by histology, strong and specific associations of earlier puberty (OR = 2.3) and mothers'' breast cancer (OR = 4.4) with nonseminomatous cancer, and of reported mononucleosis (OR = 0.3) with seminomatous cancer, were found. These observations suggest that 1) prenatal exogenous hormone exposure does not account for a significant fraction of testicular cancer, 2) a cluster of "breast-cancer-like" risk factors are associated with nonseminomas, and 3)there is some genetic risk of nonseminomas.