Flavonoids and related compounds as anti-allergic substances.
Flavonoids and related compounds as anti-allergic substances.
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DOI：
10.2332/allergolint.r-06-135
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发表时间：
2007-11
期刊：
影响因子：
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通讯作者：
M. Kawai;T. Hirano;S. Higa;J. Arimitsu;Michiru Maruta;Y. Kuwahara;T. Ohkawara;K. Hagihara;T. Yamadori;Y. Shima;A. Ogata;I. Kawase;Toshio Tanaka
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文献类型：
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作者：
M. Kawai;T. Hirano;S. Higa;J. Arimitsu;Michiru Maruta;Y. Kuwahara;T. Ohkawara;K. Hagihara;T. Yamadori;Y. Shima;A. Ogata;I. Kawase;Toshio Tanaka
在过去的二十年里，过敏性疾病的患病率在世界各地都有所增加。饮食改变被认为是导致过敏症状增加和恶化的环境因素之一。如果是这种情况，适当摄入具有抗过敏活性的食物或饮料有望预防过敏性疾病的发生并改善过敏症状。黄酮类化合物普遍存在于蔬菜、水果和茶叶中，具有抗过敏作用。黄酮类化合物抑制嗜碱性细胞组胺释放、IL-4和IL-13合成以及CD40配体表达。对45种黄酮、黄酮醇及其相关化合物的构效关系分析表明，木犀草素、紫花苋苷、芹菜素和非塞酮是抑制IL-4产生的最强抑制剂，其IC（50）值在2 ~ 5 μ m之间，并确定了抑制IL-4产生的基本结构。黄酮类化合物对IL-4和CD40配体表达的抑制作用可能是通过抑制活化T细胞核因子和AP-1的活化而介导的。黄酮类化合物对易发特应性皮炎小鼠具有预防和改善作用。最近的流行病学研究报道，在高摄入黄酮类化合物的人群中，哮喘的发病率明显较低。因此，这一证据将有助于开发用于过敏性疾病的低分子化合物，并期望膳食菜单中包含适当摄入的类黄酮可以为过敏性疾病提供一种补充和替代药物的形式和预防策略。验证这些观点的临床研究正在进行中。
The prevalence of allergic diseases has increased all over the world during the last two decades. Dietary change is considered to be one of the environmental factors that cause this increase and worsen allergic symptoms. If this is the case, an appropriate intake of foods or beverages with anti-allergic activities is expected to prevent the onset of allergic diseases and ameliorate allergic symptoms. Flavonoids, ubiquitously present in vegetables, fruits or teas possess anti-allergic activities. Flavonoids inhibit histamine release, synthesis of IL-4 and IL-13 and CD40 ligand expression by basophils. Analyses of structure-activity relationships of 45 flavones, flavonols and their related compounds showed that luteolin, ayanin, apigenin and fisetin were the strongest inhibitors of IL-4 production with an IC(50) value of 2-5 microM and determined a fundamental structure for the inhibitory activity. The inhibitory activity of flavonoids on IL-4 and CD40 ligand expression was possibly mediated through their inhibitory action on activation of nuclear factors of activated T cells and AP-1. Administration of flavonoids into atopic dermatitis-prone mice showed a preventative and ameliorative effect. Recent epidemiological studies reported that a low incidence of asthma was significantly observed in a population with a high intake of flavonoids. Thus, this evidence will be helpful for the development of low molecular compounds for allergic diseases and it is expected that a dietary menu including an appropriate intake of flavonoids may provide a form of complementary and alternative medicine and a preventative strategy for allergic diseases. Clinical studies to verify these points are now in progress.