Basic science of articular cartilage and osteoarthritis
Basic science of articular cartilage and osteoarthritis
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DOI：
10.1016/j.csm.2004.08.007
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发表时间：
2005-01-01
影响因子：
2
通讯作者：
Rodeo, SA
中科院分区：
文献类型：
--
作者：
Pearle, AD;Warren, RF;Rodeo, SA
关节软骨是一种特殊的组织，特别适合于低摩擦关节面的载荷分布。其压缩和拉伸性能由其基质和流体组成决定，并由稳态关节中的软骨细胞维持。骨关节炎（OA）逐渐被理解为一种疾病家族，其中软骨的生物力学性质被改变，并且最终由于组织被局部蛋白酶降解而失效。机械介导的和精氨酸介导的软骨退变途径已被确定在OA的发病机制中。进一步深入了解软骨和骨关节炎的基础科学是必要的，以制定诊断和治疗策略，这种普遍的疾病。
Articular cartilage is a specialized tissue uniquely suited for load distribution with a low-friction articulating surface. Its compressive and tensile properties are determined by its matrix and fluid composition, and are maintained by chondrocytes in the homeostatic joint. Osteoarthritis (OA) is increasingly understood as a family of disorders in which the biomechanical properties of cartilage are altered and ultimately fail as the tissue is degraded by local proteases. Mechanically mediated and cytokine-mediated pathways of cartilage degeneration have been identified in the pathogenesis of OA. Further insight into the basic science of cartilage and OA is necessary to develop diagnostic and treatment strategies for this pervasive disease.