Prevalence of and risk factors for fatty liver in a general population of Shanghai, China
Prevalence of and risk factors for fatty liver in a general population of Shanghai, China
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DOI：
10.1016/j.jhep.2005.02.042
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发表时间：
2005-09-01
影响因子：
25.7
通讯作者：
Chen, SY
中科院分区：
文献类型：
--
作者：
Fan, JG;Zhu, J;Chen, SY
背景/目的：确定上海成年人脂肪肝（FL）的患病率和危险因素。方法：采用随机多阶段分层整群抽样的横断面超声调查。结果：该研究包括 3175 名受试者（1218 名男性），平均年龄 52 岁。 661 名 (20.82%) 受试者中发现 FL。按年龄和性别调整后，FL 患病率为 17.29%，酒精性、疑似酒精性和非酒精性 FL 患病率分别为 0.79%、1.15% 和 15.35%。一般来说，FL患者的年龄、体重指数（BMI）、腰围、血压以及肥胖、糖尿病、高血压和血脂异常的患病率均显着高于对照组；相比之下，高密度脂蛋白胆固醇（HDL-C）、教育程度和体力活动水平则明显较低。多元回归分析显示，只有9个因素（男性、文化程度、腰围、BMI、HDL-C、甘油三酯、空腹血糖、糖尿病和高血压）与FL密切相关。在过量饮酒者中，肥胖使FL的风险增加4.8倍，但在肥胖受试者中，过量饮酒仅使FL风险增加1.5倍。结论：上海地区FL的患病率很高，主要与多种代谢紊乱有关。 (c) 2005 年欧洲肝脏研究协会。由 Elsevier B.V. 出版。保留所有权利。
Background/Aims: To determine the prevalence and risk factors of fatty liver (FL) among Shanghai adults.Methods: A cross-sectional ultrasonographic survey with randomized multistage stratified cluster sampling was used.Results: The study included 3175 subjects (1218 men) with a mean age of 52 years. FL was found in 661 (20.82%) subjects. After adjustment by age and sex, FL prevalence was found to be 17.29%, and the prevalences of alcoholic, suspected alcoholic and nonalcoholic FL were determined to be 0.79, 1.15 and 15.35%, respectively. Generally, age, body mass index (BMI), waist circumference, blood pressure, and the prevalences of obesity, diabetes, hypertension and dyslipidernia were all significantly higher in FL patients than in controls; In contrast, the levels of high-density-lipoprotein cholesterol (HDL-C), education and physical activity were markedly lower. Multiple regression analyses showed that only nine factors (male, educational level, waist circumference, BMI, HDL-C, triglyceride, fasting plasma glucose, diabetes and hypertension) were closely related to FL. In excessive drinkers, obesity increased the risk for FL by 4.8-fold, but excessive drinking was associated with only a 1.5-fold increased risk in obese subjects.Conclusions: FL in Shanghai is highly prevalent and mainly related to multiple metabolic disorders. (c) 2005 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.