Exposure to organochlorine compounds and effects on ovarian function.
Exposure to organochlorine compounds and effects on ovarian function.
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接触有机氯化合物及其对卵巢功能的影响。
DOI：
10.1097/01.ede.0000152527.24339.17
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发表时间：
2005
期刊：
影响因子：
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通讯作者：
Lasley,Bill
中科院分区：
文献类型：
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作者：
Windham,GayleC;Lee,Diana;Mitchell,Patrick;Anderson,Meredith;Petreas,Myrto;Lasley,Bill
背景：一些化学物质似乎对动物具有激素活性，但人类的数据很少。因此，我们检查了卵巢功能与有机氯化合物水平的关系。方法：1997年至1999年间，50名东南亚育龄移民妇女每天采集尿液样本。对这些样本进行雌激素和孕激素代谢物分析，并评估女性的月经周期参数。检测血清中的有机氯化合物（包括 DDT、其代谢物 DDE 和 10 种多氯联苯 [PCB] 同系物）。结果：所有样品均检测到 DDT 和 DDE，平均水平高于美国典型人群。与最低四分位浓度相比，最高四分位数浓度的 DDT 或 DDE 的平均周期长度大约缩短 4 天。在调整血脂水平、年龄、产次和输卵管结扎，并排除特别长的周期后，减量衰减至不到 1 天，具有较宽的置信区间 (CI)。在 DDT（95% CI=− 2.6 至− 0.30）或 DDE（− 2.6 至− 0.20）最高四分位处，调整后的平均黄体期长度缩短约 1.5 天。随着 DDE 水平每增加一倍，周期长度减少 1.1 天（− 2.4 至 0.23），黄体期长度减少 0.6 天（− 1.1 至− 0.2）。黄体期的孕酮代谢水平随着 DDE 浓度的升高而持续降低。调整后，PCB 水平通常与周期长度或激素参数无关，并且当包含在同一模型中时，它们不会改变 DDE 关联。结论：这项研究表明 DDE 对卵巢功能的潜在影响，这可能会影响其他终点，如生育力、妊娠和生殖系统癌症。
Background:Some chemicals appear to have hormonally active properties in animals, but data in humans are sparse. Therefore, we examined ovarian function in relation to organochlorine compound levels.Methods:During 1997–1999, 50 Southeast Asian immigrant women of reproductive age collected urine samples daily. These samples were assayed for metabolites of estrogen and progesterone, and the women's menstrual cycle parameters were assessed. Organochlorine compounds (including DDT, its metabolite DDE, and 10 polychlorinated biphenyl [PCB] congeners) were measured in serum.Results:All samples had detectable DDT and DDE, with mean levels higher than typical US populations. Mean cycle length was approximately 4 days shorter at the highest quartile concentration of DDT or DDE compared with the lowest. After adjustment for lipid levels, age, parity, and tubal ligation, and exclusion of a particularly long cycle, the decrements were attenuated to less than 1 day, with wide confidence intervals (CIs). The adjusted mean luteal phase length was shorter by approximately 1.5 days at the highest quartile of DDT (95% CI=− 2.6 to− 0.30) or DDE (− 2.6 to− 0.20). With each doubling of the DDE level, cycle length decreased 1.1 day (− 2.4 to 0.23) and luteal phase length decreased 0.6 days (− 1.1 to− 0.2). Progesterone metabolite levels during the luteal phase were consistently decreased with higher DDE concentration. PCB levels were not generally associated with cycle length or hormone parameters after adjustment, and they did not alter the DDE associations when included in the same models.Conclusions:This study indicates a potential effect of DDE on ovarian function, which may influence other end points such as fertility, pregnancy, and reproductive cancers.