Enantioselective total synthesis of enokipodins A-D
Enantioselective total synthesis of enokipodins A-D
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DOI：
10.1016/j.tetlet.2004.04.191
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发表时间：
2004-06-21
影响因子：
1.8
通讯作者：
Saito, M
中科院分区：
文献类型：
--
作者：
Kuwahara, S;Saito, M
通过使用 Meyers 的非对映选择性烷基化方案构建 C7-四元不对称中心，首次对映选择性全合成了 enokipodins A-D（具有抗菌活性的高度氧化的 α-cuparenone 型倍半萜类化合物）。本合成还构成了(S)-1,4-铜烯二醇和(S)-铜烯-1,4-醌的正式对映选择性合成。 (C) 2004 Elsevier Ltd. 保留所有权利。
The first enantio selective total synthesis of enokipodins A-D, highly oxidized alpha-cuparenone-type sesquiterpenoids with antimicrobial activity, was accomplished by using Meyers' diastereoselective alkylation protocol for the construction of the C7-quaternary asymmetric center. The present synthesis also constitutes a formal enantioselective synthesis of (S)-1,4-cuparenediol and (S)-cuparene-1,4-quinone. (C) 2004 Elsevier Ltd. All rights reserved.