A short, stereocontrolled, and practical synthesis of α-methylomuralide, a potent inhibitor of proteasome function
A short, stereocontrolled, and practical synthesis of α-methylomuralide, a potent inhibitor of proteasome function
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DOI：
10.1021/jo0268916
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发表时间：
2003-04-04
影响因子：
3.6
通讯作者：
Corey, EJ
中科院分区：
文献类型：
--
作者：
Saravanan, P;Corey, EJ
An efficient and practical synthesis of alpha-methylomuralide (3), a selective inhibitor of proteasomes, has been developed as outlined in Scheme 1. Among the advantages of this route of synthesis over previously described approaches are (1) ease of scale-up and (2) high yields (28% overall yield of a-methylomuralide from 6) and stereocontrol (including high enantiocontrol). The synthesis is well suited to the production of 3 in the quantities needed for material-intensive in vivo investigations.
