von Recklinghausen neurofibroma produces neuronal and glial growth-modulating factors
von Recklinghausen neurofibroma produces neuronal and glial growth-modulating factors
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冯·雷克林豪森神经纤维瘤产生神经元和神经胶质生长调节因子
DOI：
10.1016/0006-8993(91)90328-s
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发表时间：
1991
期刊：
影响因子：
2.9
通讯作者：
Taiji Kato
中科院分区：
文献类型：
--
作者：
K. Asai;T. Hotta;K. Nakanishi;J. Ito;R. Tanaka;T. Otsuka;N. Matsui;Taiji Kato
目前在von Recklinghausen神经纤维瘤（NF 1）提取物中检测到两种新的神经营养因子。其中一种是生长因子神经母细胞瘤生长因子（Mr<5kDa），它能促进人神经母细胞瘤细胞的增殖和大鼠皮层神经元的存活和突起的延伸，但与神经生长因子（NGF）类因子不同。另一个是胶质细胞生长抑制剂（Mr=100kDa），其抑制胶质瘤细胞系、星形细胞瘤、胶质母细胞瘤、少突胶质细胞瘤和神经鞘瘤的生长。这些因子似乎不是先前鉴定的细胞因子或生长因子，例如白细胞介素、粒细胞集落刺激因子、NGF和成纤维细胞生长因子。提取物中也有可检测到的睫状神经营养因子样活性。这些因子在NF1中高含量的主要原因尚不清楚，但可能与神经系统发育过程中控制神经元和胶质细胞生长和分化的基本机制有关。
Two kinds of novel neural trophic factors were currently detected in von Recklinghausen neurofibroma (NF1) extracts. One of the two was a growth factor, neuroblastoma growth factor (Mr<5kDa), which promotes the proliferation of human neuroblastoma cell and survival and neurite-extension of rat cortical neurons, but differently from nerve growth factor (NGF) of NGF-like factors. The other one was a glial growth inhibitor (Mr=100kDa), which suppresses the growth of glioma cell lines, astrocytoma, glioblastoma, oligodendroglioma and Schwannoma. These factors do not appear to be previously identified cytokines or growth factors such as interleukins, granulocyte colony-stimulating factor, NGF and fibroblast growth factor. There was also detectable ciliary neurotrophic factor-like activity in the extracts. The primary cause of high contents of these factors in NF1 is not known, but may relate to fundamental mechanisms controlling growth and differentiation of neurons and glias during development of nervous system.