The immunoglobulin (IgG) antibody response to OspA and OspB correlates with severe and prolonged Lyme arthritis and the IgG response to P35 correlates with mild and brief arthritis
The immunoglobulin (IgG) antibody response to OspA and OspB correlates with severe and prolonged Lyme arthritis and the IgG response to P35 correlates with mild and brief arthritis
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DOI：
10.1128/iai.67.1.173-181.1999
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发表时间：
1999-01-01
影响因子：
3.1
通讯作者：
Steere, AC
中科院分区：
文献类型：
--
作者：
Akin, E;McHugh, GL;Steere, AC
在努力牵连特定的伯氏疏螺旋体蛋白的免疫反应，可能在慢性莱姆关节炎的作用，我们研究了抗体反应的自然史B。在莱姆病的整个过程中监测的25名患者的系列血清样品中的伯氏螺旋体。在这些患者中，免疫球蛋白G（IgM）和IgE抗体对10种重组B。在早期感染、早期关节炎和最大关节炎期间测定的伯氏菌蛋白与最大关节炎的严重程度和持续时间相关。最早的反应通常是对外表面蛋白C（OspC），P35，P37和P41的反应;与OspE，OspF，P39和P93的反应通常在几周后发生：数月至数年后，64%的患者对OspA和OspB有反应。在早期感染和早期关节炎中，P35 IgG抗体水平与随后最大关节炎的严重程度或持续时间呈负相关。相反，在最大关节炎期间，OspA和OspB的IgG抗体水平，特别是OspA的C-末端表位，与关节炎的严重程度和持续时间直接相关。因此，感染早期对P35的IgG抗体应答越高，随后的关节炎越轻和越短，而在最大关节炎期间，对OspA和OspB的IgG应答越高，关节炎越严重和延长。
In an effort to implicate immune responses to specific Borrelia burgdorferi proteins that may have a role in chronic Lyme arthritis, we studied the natural history of the antibody response to B. burgdorferi in serial serum samples from 25 patients monitored throughout the course of Lyme disease. In these patients, the immunoglobulin G (IgM) and Ige antibody responses to 10 recombinant B. burgdorferi proteins, determined during early infection, early arthritis, and maximal arthritis, were correlated with the severity and duration of maximal arthritis. The earliest responses were usually to outer surface protein C (OspC), P35, P37, and P41; reactivity with OspE, OspF, P39, and P93 often developed weeks later: and months to years later, 64% of patients had responses to OspA and OspB. During early infection and early arthritis, the levels of IgG antibody to P35 correlated inversely with the subsequent severity or duration of maximal arthritis. In contrast, during periods of maximal arthritis, the levels of IgG antibody to OspA and OspB, especially to a C-terminal epitope of OspA, correlated directly with the severity and duration of arthritis. Thus, the higher the IgG antibody response to P35 earlier in the infection, the milder and briefer the subsequent arthritis, whereas during maximal arthritis, the higher the IgG response to OspA and OspB, the more severe and prolonged the arthritis.