The association of age and semen quality in healthy men
The association of age and semen quality in healthy men
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DOI：
10.1093/humrep/deg107
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发表时间：
2003-02-01
影响因子：
6.1
通讯作者：
Moore, D
中科院分区：
文献类型：
--
作者：
Eskenazi, B;Wyrobek, AJ;Moore, D
背景：尽管母亲年龄对生育力的影响众所周知，但尚不清楚父亲年龄是否也会影响生育力。这项横断面研究旨在描述年龄和精液质量之间的关系，精液质量是众所周知的生育状况指标。方法：从国家政府实验室招募了 97 名没有已知生育问题的不吸烟男性（年龄 22-80 岁）作为方便样本。这些男子提供了精液样本以及有关生活方式、饮食、医疗和职业细节的信息。测量精液体积(ml)、精子浓度(X 10(6)/ml)、精子总数(X 106)、活力(%)、渐进活力(%)和渐进运动精子总数(X 10(6))。结果：调整协变量后，精液量每年减少 0.03 ml（95% Cl：4.05,4.01）；活力每年下降 0.7%（95% CI：-0.92，-0.43）；前向运动能力每年下降 3.1%（95% CI：-4.5，-1.6）；渐进运动精子总数每年减少 4.7%（95% CI：-7.2，-2.2）。建议精子浓度和数量有所下降。在几十年的时间里，体积、注意力和活动能力异常的男性比例显着增加。结论：在来自非临床环境的健康男性的方便样本中，精液量和精子活力在 22-80 岁之间持续下降，没有证据表明存在阈值。
BACKGROUND: Although the effect of maternal age on fertility is well known, it is unclear whether paternal age also affects fertility. This cross-sectional study sought to characterize the association between age and semen quality, a well-known proxy of fertility status. METHODS: A convenience sample of 97 non-smoking men (aged 22-80 years) without known fertility problems was recruited from a national government laboratory. The men provided semen samples and information relating to lifestyle, diet, medical and occupational details. Semen volume (ml), sperm concentration (X 10(6)/ml), total sperm count (X 106), Motility (%), progressive motility (%) and total progressively motile sperm count (X 10(6)) were measured. RESULTS: After adjusting for covariates, semen volume decreased by 0.03 ml per year of age (95% Cl: 4.05,4.01); motility decreased by 0.7% per year (95% CI: -0.92, -0.43); progressive motility decreased by 3.1 % per year (95 % CI: -4.5, -1.6); and total progressively motile sperm count decreased by 4.7% per year (95% CI: -7.2, -2.2). There was a suggested decrease in sperm concentration and count. The proportion of men with abnormal volume, concentration and motility was significantly increased across the age decades. CONCLUSIONS: In a convenience sample of healthy men from a non-clinical setting, semen volume and sperm motility decreased continuously between 22-80 years of age, with no evidence of a threshold.