Short-term preoperative radiotherapy interferes with the determination of pathological parameters in rectal cancer
Short-term preoperative radiotherapy interferes with the determination of pathological parameters in rectal cancer
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DOI：
10.1002/path.1098
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发表时间：
2002-05-01
影响因子：
7.3
通讯作者：
van Krieken, JHJM
中科院分区：
文献类型：
--
作者：
Nagtegaal, ID;Marijnen, CAM;van Krieken, JHJM
短期术前放疗结合手术已被证明可以降低直肠癌患者的局部复发率。这种类型的放射治疗对直肠癌的组织病理学的影响迄今尚不清楚。由于各种组织病理学因素与预后相关，因此研究辐射引起的变化是一个重要问题。本文研究了1306例患者的切除标本的组织病理学，这些患者在一项随机试验中接受了治疗，该试验评估了术前放疗的益处。在本试验中，患者接受短期放疗（5 × 5戈伊），并在放疗后5天内进行手术。组织学参数由试验的病理学审查委员会确定，我们比较了术前放疗和未放疗患者的肿瘤。术前接受放疗的患者肿瘤较小，多为粘液癌（13%对7%，p
Short-term preoperative radiotherapy in combination with surgery has been shown to decrease the rate of local recurrence in rectal cancer patients. The effects of this type of radiotherapy on the histopathology of rectal carcinoma has been hitherto unknown. Since various histopathological factors are associated with prognosis, the study of alterations induced by irradiation is an important issue. This paper examines the histopathology of resection specimens from 1306 patients who were treated in a randomized trial that evaluated the benefits of preoperative radiotherapy. In this trial, patients were treated with short-term radiotherapy (5x5 Gy) and operated on within 5 days after radiation. Histopathological parameters were determined by the Pathology Review Committee of the trial and we compared tumours of patients with and without preoperative radiotherapy. Tumours of patients who were treated with preoperative radiotherapy were smaller, more often mucinous carcinomas (13% versus 7%, p