Understanding cytokines. Part I: Physiology and mechanism of action.
Understanding cytokines. Part I: Physiology and mechanism of action.
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DOI：
10.1177/109980040000200104
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发表时间：
2000-07-01
影响因子：
2.5
通讯作者：
Corwin, E J
中科院分区：
文献类型：
--
作者：
Corwin, E J
这是关于理解细胞因子的两部分文章中的第一部分。细胞因子是从几乎所有有核细胞释放的细胞间信号蛋白，其影响广泛组织中的生长和细胞增殖。细胞因子具有免疫调节作用，并且被理解为控制与感染和炎症相关的大多数身体和心理症状。细胞因子也影响生殖和骨重建。细胞因子细胞系统的失调在多种疾病的发展中具有重要意义，包括大多数自身免疫性疾病、心血管系统的许多疾病、骨质疏松症、哮喘和抑郁症。对于护士充分知情时，照顾客户与慢性疾病，并有足够的知识时，评估客户端的结果，细胞因子的生理学的理解，失调的发生，细胞因子在健康和疾病的作用是必不可少的。在第一部分的审查，细胞因子生理学，重点是特点，类别和作用机制。第二部分介绍了细胞因子在健康和疾病中的作用及其对护理研究和实践的影响。
This is the first of a 2-part article on understanding cytokines. Cytokines are intercellular signaling proteins released from virtually all nucleated cells that influence growth and cellular proliferation in a wide range of tissues. Cytokines have immune modulating effects and are understood to control most of the physical and psychological symptoms associated with infection and inflammation. Cytokines also influence reproduction and bone remodeling. Dysregulation of the cytokine cellular system has significant implications in the development of a variety of illnesses, including most autoimmune disorders, many diseases of the cardiovascular system, osteoporosis, asthma, and depression. For nurses to be adequately informed when caring for clients with chronic illnesses and to be sufficiently knowledgeable when evaluating client outcomes, an understanding of the physiology of cytokines, the occurrences of dysregulation, and the role of cytokines in health and illness is essential. In Part I of this review, cytokine physiology is presented, with an emphasis on characteristics, categories, and mechanism of action. Specific instances of cytokine function in health and disease and implications for nursing research and practice are presented in Part II.