The measurement of exhaled carbon monoxide is influenced by airflow obstruction
The measurement of exhaled carbon monoxide is influenced by airflow obstruction
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DOI：
10.1183/09031936.00.15117700
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发表时间：
2000-01-01
影响因子：
24.3
通讯作者：
Agustí, AGN
中科院分区：
文献类型：
--
作者：
Togores, B;Bosch, M;Agustí, AGN
碳氧血红蛋白（COHb）的浓度通常通过测量呼出空气中的一氧化碳（COexh）来估计。本研究旨在探讨是否存在气流阻塞显着改变COexh和COHb之间的关系。81例经常吸烟者进行了前瞻性研究，并根据气流阻塞的存在和严重程度分为四组（无，轻度，中度，重度）。在每例受试者中，作者按以下顺序测量：1）动脉血气; 2）血红蛋白浓度和COHb（通过CO血氧测定法）; 3）COexh; 4）肺容量; 5）用力肺活量测定法。测量误差的大小（Δ CO）是从COHb和COexh之间的差异计算出来的。在研究的四组受试者中，吸烟史和COexh都没有差异。相反，Δ CO增加平行于气流阻塞的程度。仅在严重气流阻塞患者中，Δ CO>2%（临床上通常用于区分吸烟者和非吸烟者的阈值）。逐步多因素分析显示，第一秒用力呼气量（FEV 1）（参考百分比）和COHb均显著（p
The concentration of carboxyhaemoglobin (COHb) is often estimated from measurements of carbon monoxide in the exhaled air (COexh). This study investigates whether the presence of airflow obstruction significantly alters the relationship between COexh and COHb.Eighty-one regular smokers were prospectively studied and divided in four groups according to the presence and severity of airflow obstruction (none, mild, moderate, severe). In each subject, the authors measured in this order: 1) arterial blood gases; 2) haemoglobin concentration and COHb (by co-oxymetry); 3) COexh; 4) lung volumes; and 5) forced spirometry. The size of the measurement error (Delta CO) was calculated from the difference between COHb and COexh.Neither the smoking history nor COexh were different in the four groups of subjects studied. In contrast, Delta CO increased in parallel to the degree of airflow obstruction. Delta CO was >2% (a threshold value normally used in the clinic to separate smokers from nonsmokers) only in patients with severe airflow obstruction. A stepwise multivariate analysis showed that both forced expiratory volume in one second (FEV1) (percentage reference) and COHb contributed significantly (p