Hepatic venular pressures of rats, dogs, and rabbits.

Hepatic venular pressures of rats, dogs, and rabbits.
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大鼠、狗和兔子的肝小静脉压力。

DOI:
10.1152/ajpgi.1991.261.3.g539
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发表时间:
1991
期刊:
The American journal of physiology
影响因子:
--
通讯作者:
Rothe,CF
Rothe,CF
中科院分区:
--
文献类型:
--
作者:
Bohlen,HG;Maass-Moreno,R;Rothe,CF

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我们检验了以下假设:肝窦下游的肝小静脉压力(Phv)与门静脉压力(Ppv)非常相似(小于2 mmHg),表明肝静脉阻力较高,或与下腔静脉压力(Pivc)非常相似(小于2 mmHg),表明门静脉-窦静脉阻力较高,如先前研究者所报告。对大鼠、犬和兔使用微量移液管伺服零位压力测量技术。Phv是指腔静脉的解剖水平,大鼠、幼犬和家兔的平均值分别为5.1 +/- 1.0、6.4 +/- 1.1和5.4 +/- 1.0(SD)mmHg。Ppv平均值分别为8.0 ± 1.4、10.8 ± 2.2和7.4 ± 1.5 mmHg。门静脉输注去甲肾上腺素(1-5 μ g·min-1·kg-1)可引起Ppv增加,门静脉血流量减少,但对Phv无明显影响。在对照条件下,肝静脉回路占总肝静脉血管阻力的44 +/- 17%(大鼠)和31 +/- 26%(犬)。我们的结论是,门静脉和窦血管是占主导地位的,但不是唯一的,在休息和去甲肾上腺素诱导的血管收缩的肝静脉血管的阻力网站。
We tested the hypotheses that the hepatic venule pressures (Phv), just downstream from the hepatic sinusoids, are closely similar (less than 2 mmHg) either to the portal venous pressure (Ppv), indicating a high hepatic venous resistance, or to the inferior vena cava (Pivc) pressure, indicating a high portal-sinusoidal venous resistance, as reported by previous investigators. A micropipette servo-null pressure measurement technique was used with rats, dogs, and rabbits. Phv, referred to the anatomic level of the vena cava, averaged 5.1 +/- 1.0, 6.4 +/- 1.1, and 5.4 +/- 1.0 (SD) mmHg in the rats, puppies, and rabbits, respectively. Ppv averaged 8.0 +/- 1.4, 10.8 +/- 2.2, and 7.4 +/- 1.5 mmHg, respectively. Norepinephrine infusion into the portal vein (1-5 micrograms.min-1.kg-1) caused Ppv to increase and the portal venous flow to decrease but did not significantly affect Phv. The hepatic venous circuit contributed 44 +/- 17% (rats) and 31 +/- 26% (dogs) of the total liver venous vascular resistance under control conditions. We conclude that the portal and sinusoidal vasculatures are the dominant, but not exclusive, resistance sites of the liver venous vasculature both at rest and during norepinephrine-induced vasoconstriction.
DOI: 10.1085/jgp.79.3.437
发表时间: 1982-03
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影响因子: --
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发表时间: 1982
期刊: Life sciences
影响因子: 6.1
作者:
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DOI: --
发表时间: 1984
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影响因子: --
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