Postural-induced phase shift of respiratory sinus arrhythmia and blood pressure variations: insight from respiratory-phase domain analysis.
Postural-induced phase shift of respiratory sinus arrhythmia and blood pressure variations: insight from respiratory-phase domain analysis.
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DOI：
10.1152/ajpheart.00680.2007
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发表时间：
2008-03
期刊：
影响因子：
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通讯作者：
K. Kotani;K. Takamasu;Y. Jimbo;Yoshiharu Yamamoto
中科院分区：
文献类型：
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作者：
K. Kotani;K. Takamasu;Y. Jimbo;Yoshiharu Yamamoto
本研究的目的是通过分析呼吸性窦性心律失常（RSA）和呼吸相关血压（BP）变化（收缩压（SBP）、舒张压（DBP），评估呼吸对不同姿势下心血管变异性的多重影响。呼吸相域中的脉搏压（PP）。在健康人的坐姿和站立位上进行420 s的测量，同时连续监测受试者的心率和BP变异性以及瞬时肺容量。RSA的波形和呼吸相关的BP变化被提取为呼吸相位的函数。在站立位，SBP、DBP和PP的BP变化的波形在呼气末（pi rad）附近显示其最大值，在吸气末（2 pi rad）附近显示其最小值，而RSA的波形与BP波形相比延迟约0.35 pi rad。另一方面，在坐位时，DBP波形的相位（1.69 π rad）与站立位时的相位（1.20 π rad）有很大且显著的差异（P < 0.01）。坐位时PP相延迟，RSA相提前（P < 0.01）。特别地，DBP波形的相移足够大以改变整个血液动力学波动，从而影响SBP和PP变化的幅度。我们的结论是，与自主神经平衡改变相关的姿势变化不仅影响RSA的幅度，而且RSA和BP变化的相位以复杂的方式，本研究中使用的相位域分析是有用的，以阐明RSA的动力学机制。
The purpose of this study is to evaluate the multiple effects of respiration on cardiovascular variability in different postures, by analyzing respiratory sinus arrhythmia (RSA) and respiratory-related blood pressure (BP) variations for systolic BP (SBP), diastolic BP (DBP), and pulse pressure (PP) in the respiratory-phase domain. The measurements were conducted for 420 s on healthy humans in the sitting and standing positions, while the subjects were continuously monitored for heart rate and BP variability and instantaneous lung volume. The waveforms of RSA and respiratory-related BP variations were extracted as a function of the respiratory phase. In the standing position, the waveforms of the BP variations for SBP, DBP, and PP show their maxima at around the end of expiration (pi rad) and the minima at around the end of inspiration (2 pi rad), while the waveform of RSA is delayed by approximately 0.35 pi rad compared with the BP waveforms. On the other hand, in the sitting position, the phase of the DBP waveform (1.69 pi rad) greatly and significantly (P < 0.01) differs from that in the standing position (1.20 pi rad). Also, the phase of PP is delayed and that of RSA is advanced in the sitting position (P < 0.01). In particular, the phase shift of the DBP waveform is sufficiently large to alter whole hemodynamic fluctuations, affecting the amplitudes of SBP and PP variations. We conclude that the postural change associated with an altered autonomic balance affects not only the amplitude of RSA, but also the phases of RSA and BP variations in a complicated manner, and the respiratory-phase domain analysis used in this study is useful for elucidating the dynamic mechanisms of RSA.