Role of plasma membrane defect of skeletal muscle in malignant hyperthermia
Role of plasma membrane defect of skeletal muscle in malignant hyperthermia
复制标题
骨骼肌质膜缺陷在恶性高热中的作用
作者：
E. Gallant;R. Godt;G. Gronert
氟烷在临床浓度下，可使易患恶性高热的波兰中国猪骨骼肌的质膜去极化，但不影响正常波兰中国猪、小鼠或青蛙肌肉的静息膜电位。在丹曲仑钠的存在下，去极化减少或部分逆转。我们认为恶性热疗可能是由氟烷引起的骨骼肌异常去极化引起的。
Halothane, at clinical concentrations, depolarizes the plasma membrane of skeletal muscle from Poland China pigs susceptible to malignant hyperthermia but does not affect the resting membrane potential of muscle from normal Poland China pigs, mice, or frogs. The depolarization is reduced or partially reversed in the presence of dantrolene sodium. We suggest the possibility that malignant hyperthermia may be initiated by this abnormal depolarization of skeletal muscle by halothane.