DIETARY POTASSIUM AND STROKE-ASSOCIATED MORTALITY - A 12-YEAR PROSPECTIVE POPULATION STUDY
DIETARY POTASSIUM AND STROKE-ASSOCIATED MORTALITY - A 12-YEAR PROSPECTIVE POPULATION STUDY
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DOI：
10.1056/nejm198701293160502
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发表时间：
1987-01-29
影响因子：
158.5
通讯作者：
BARRETTCONNOR, E
中科院分区：
文献类型：
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作者：
KHAW, KT;BARRETTCONNOR, E
高血压是中风最重要的已知危险因素。临床、实验和流行病学证据表明，高钾饮食摄入量与低血压相关。在高血压大鼠中，据报道，高钾摄入量可以防止中风，即使血压没有受到影响。我们在南加州的859名男性和女性（年龄50 - 79岁）的人群队列中研究了基线24小时膳食钾摄入量与随后卒中相关死亡率之间的关系。12年后，发生了24例与中风相关的死亡。钾摄入量最低的三分位数与最高的两个三分位数相比较，中风相关死亡率的相对风险在男性中为2.6（P = 0.16），在女性中为4.8（P = 0.01）。在多变量分析中，每日钾摄入量增加10 mmol与卒中相关死亡风险降低40%相关（P < 0.001）。这种影响与其他饮食变量无关，包括卡路里，脂肪，蛋白质，纤维，钙，镁和酒精的摄入量。该效应也明显独立于已知的心血管危险因素，包括年龄、性别、血压、血胆固醇水平、肥胖、空腹血糖水平和吸烟。这些发现支持了从食物中摄入大量钾可以预防中风相关死亡的假设。
Hypertension is the most important known risk factor for stroke. Clinical, experimental, and epidemiologic evidence suggests that a high dietary intake of potassium is associated with lower blood pressure. In hypertensive rats, a high intake of potassium is reported to protect against stroke, even though blood pressure is no affected. We examined the relation between the 24-hour dietary potassium intake at base line and subsequent stroke-associated mortality in a population-based cohort of 859 men and women (aged 50 to 79 years) in Southern California. After 12 years, 24 stroke-associated deaths had occurred. The relative risks of stroke-associated mortality in the lowest tertile of potassium intake, as compared with that in the top two tertiles combined, were 2.6 (P = 0.16) in men and 4.8 (P = 0.01) in women. In multivariate analyses, a 10-mmol increase in daily potassium intake was associated with a 40 percent reduction in the risk of stroke-associated mortality (P < 0.001). This effect was independent of other dietary variables, including the intake of calories, fat, protein, fiber, calcium, magnesium, and alcohol. The effect was also apparently independent of known cardiovascular risk factors, including age, sex, blood pressure, blood cholesterol level, obesity, fasting blood glucose level, and cigarette smoking. These findings support the hypothesis that a high intake of potassium from food sources may protect against stroke-associated death.