Cancer stem cells as new therapeutic target to prevent tumour progression and metastasis.
Cancer stem cells as new therapeutic target to prevent tumour progression and metastasis.
复制标题
DOI：
10.2741/e117
复制
发表时间：
2010-01-01
期刊：
影响因子：
--
通讯作者：
Heeschen, Christopher
中科院分区：
文献类型：
--
作者：
Mueller, Maria-Theresa;Hermann, Patrick C;Heeschen, Christopher
在过去的十年中，越来越多的证据表明，干细胞不仅在复杂的多细胞生物体的产生中起着至关重要的作用，而且在恶性疾病的发展和进展中也起着至关重要的作用。对于最丰富的肿瘤，已经表明它们含有独特的癌细胞亚群，其专门负责肿瘤的起始和增殖。这些细胞被称为癌症干细胞或肿瘤起始细胞，并且它们对化疗剂也具有高度抗性。由于CSC优先被赋予自我更新能力，因此进一步假设它们也专门负责转移。事实上，我们能够证明胰腺癌干细胞含有以CXCR4共表达为特征的迁移性癌症干细胞亚群。只有这些细胞才能避开原发肿瘤并转移。世界各地的实验室现在正致力于进一步表征这些细胞，以最终确定对抗癌症的新型治疗方法。因此，癌症干细胞是有希望的新靶点，以抵消实体瘤的生长促进和转移潜力。
Over the past decade, increasing evidence suggested that stem cells play a crucial role not only in the generation of complex multicellular organisms, but also in the development and progression of malignant diseases. For the most abundant tumours, it has been shown that they contain a subset of distinct cancer cells that is exclusively responsible for tumour initiation and propagation These cells are termed cancer stem cells or tumour-initiating cells and they are also highly resistant to chemotherapeutic agents. Because CSC are preferentially endowed with the self-renewal capacity, it has further been hypothesized that they are also exclusively responsible for metastasis. Indeed, we were able to show that pancreatic cancer stem cells contain a subpopulation of migrating cancer stem cells characterized by CXCR4 co-expression. Only these cells are capable of evading the primary tumour and metastasizing. Laboratories around the world are now aiming to further characterize these cells to eventually identify novel treatment modalities to fight cancer. Thus, cancer stem cells are promising new targets to counteract the growth-promoting and metastatic potential of solid tumours.