Coptidis Rhizoma Water Extract Stimulates 5′-AMP-Activated Protein Kinase in Rat Skeletal Muscle
Coptidis Rhizoma Water Extract Stimulates 5′-AMP-Activated Protein Kinase in Rat Skeletal Muscle
复制标题
DOI：
10.3724/sp.j.1009.2011.00215
复制
发表时间：
2011-05
影响因子：
4.6
通讯作者：
Xiao Ma;T. Egawa;Rieko Oshima;Eriko Kurogi;H. Tanabe;S. Tsuda;Tatsuya Hayashi
中科院分区：
文献类型：
--
作者：
Xiao Ma;T. Egawa;Rieko Oshima;Eriko Kurogi;H. Tanabe;S. Tsuda;Tatsuya Hayashi
目的黄连（Coptis chinensis Franch）为亚洲草本植物黄连（Coptis chinensis Franch）的干燥根茎，用于治疗糖尿病已有数千年的历史。我们探讨了CR直接作用于骨骼肌（负责葡萄糖稳态的主要器官）并激活5′-AMP活化蛋白激酶（AMPK）的可能性，AMPK是导致骨骼肌代谢增强的信号中介。
Aim Coptidis Rhizoma (CR), the dried rhizomes of Asian herbs (including Coptis chinensis Franch), has been used to treat diabetes mellitus for thousands of years. We explored the possibility that CR acts directly on skeletal muscle, the major organ responsible for glucose homeostasis, and activates 5′-AMP-activated protein kinase (AMPK), a signaling intermediary leading to metabolic enhancement of skeletal muscle.