Oxidative damage to DNA: Inhibition of guanine damage
Oxidative damage to DNA: Inhibition of guanine damage
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DOI：
10.1351/pac200678122297
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发表时间：
2006-12-01
影响因子：
1.8
通讯作者：
Schuster, Gary B.
中科院分区：
文献类型：
--
作者：
Kanvah, Sriram;Schuster, Gary B.
DNA的单电子氧化导致对碱基的化学损伤，特别是多个G序列中的鸟嘌呤。氧化可能由许多事件触发，包括光敏作用。我们描述了在影响DNA全局结构的各种条件下，由共价连接的蒽醌衍生物引发的DNA光诱导氧化的研究。这些结构变化对单电子氧化的结果有微妙的影响。
One-electron oxidation of DNA results in chemical damage to nucleobases, particularly guanine in multiple G sequences. Oxidation may be triggered by numerous events, including photosensitization. We describe studies of photoinduced oxidations of DNA triggered by irradiation of covalently linked anthraquinone derivatives under various conditions that affect the global structure of the DNA. These structural changes have subtle effects on the result of the one-electron oxidation.