Lessons from experimental Mycobacterium tuberculosis infections
Lessons from experimental Mycobacterium tuberculosis infections
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DOI：
10.1016/j.micinf.2005.10.033
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发表时间：
2006-04-01
影响因子：
5.8
通讯作者：
Flynn, JoAnne L.
中科院分区：
文献类型：
--
作者：
Flynn, JoAnne L.
结核分枝杆菌是每年造成巨大人类发病率和死亡率的原因。虽然这种细菌可以感染许多动物并引起疾病，但人类是天然宿主。为研究M.结核病，以及针对该病原体的保护性和免疫病理宿主反应，必须使用合适的动物模型。然而，在动物中模拟人类感染和疾病可能很困难，必须仔细解释动物模型的数据。本文对结核病动物模型进行了讨论，并对各种模型的局限性和优点进行了分析。特别是，我们从小鼠模型中学到的关于结核病的经验教训被强调。仔细和周到的使用动物模型是必不可少的，以进一步了解M。这些知识将有助于发现更好的治疗和预防策略。(c)2006年，Elsevier SAS。All rights reserved.
Mycobacterium tuberculosis is the cause of enormous human morbidity and mortality each year. Although this bacterium can infect and cause disease in many animals, humans are the natural host. For the purposes of studying the pathogenesis of M. tuberculosis, as well as the protective and immunopathologic host responses against this pathogen, suitable animal models must be used. However, modeling the human infection and disease in animals can be difficult, and interpreting the data from animal models must be done carefully. In this paper, the animal models of tuberculosis are discussed, as well as the limitations and advantages of various models. In particular, the lessons we have learned about tuberculosis from the mouse models are highlighted. The careful and thoughtful use of animal models is essential to furthering our understanding of M. tuberculosis, and this knowledge will enhance the discovery of improved treatment and prevention strategies. (c) 2006 Elsevier SAS. All rights reserved.