The Deformation Rate of Smooth Muscle Cells in Vessel Walls After Short-Duration Heating Dilatation in a Porcine Model Ex Vivo and In Vivo
The Deformation Rate of Smooth Muscle Cells in Vessel Walls After Short-Duration Heating Dilatation in a Porcine Model Ex Vivo and In Vivo
复制标题
猪离体和体内模型短时加热扩张后血管壁平滑肌细胞的变形率
DOI：
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发表时间：
2012
影响因子：
1.8
通讯作者：
T. Arai
中科院分区：
文献类型：
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作者：
Mie Kunio;T. Arai
我们提出了一种具有均匀温度分布的短时间热血管成形术。虽然我们之前的研究报告了短时间加热扩张的扩张机制，但对平滑肌细胞（SMCs）的影响尚未充分了解。我们从形状变化的角度研究了对SMCs的影响，并讨论了SMCs形状变化与体外和体内扩张机制的关系。我们发现SMCs在体外和体内经过短时间的加热扩张后，在拉伸状态下都是固定的。随着球囊最高温度（Tballoon）的升高，SMCs的形状变形率增加，动脉扩张率也有相同的趋势。我们假设SMCs在拉伸状态下是固定的，因为我们的短时间加热扩张的动脉扩张没有任何血管壁的塑性变形，导致血管壁本身被拉伸。我们还预测SMCs形状变形率与Tballoon呈正相关的原因是(i)加热超过60°C的面积随着Tballoon的升高而扩大，（ii）动脉扩张率也随着Tballoon的升高而增加。
We have proposed a novel short-duration thermal angioplasty with uniform temperature distribution. Although the dilatation mechanism of our short-duration heating dilatation was reported in our previous study, the influences on smooth muscle cells (SMCs) are not sufficiently understood. We studied the influences on SMCs in terms of shape change and discussed the relationship between the SMCs’ shape change and dilatation mechanism ex vivo and in vivo. We found that the SMCs were fixed in the stretched condition after our short-duration heating dilatation both ex vivo and in vivo. The deformation rate of SMCs’ shape, measured by the cells’ nuclei, was increased with rising balloon maximum temperature (Tballoon), and the same tendency was observed for the arterial dilatation rate. We hypothesize that the SMCs were fixed in the stretched condition because the arterial dilatation with our short-duration heating dilatation was performed without any plastic deformations of the vessel wall, causing the vessel wall itself to be stretched. We also prospect that the reasons for the positive correlation between the deformation rate of SMCs’ shape and Tballoon are that (i) the area heated over 60 °C was expanded with rising Tballoon, and (ii) the arterial dilatation rate was also increased with rising Tballoon.
激光球囊血管成形术：临床、血管造影和组织学结果。
影响因子：
24
作者：
Reis,GJ;Pomerantz,RM;Jenkins,RD;Kuntz,RE;Baim,DS;Diver,DJ;Schnitt,SJ;Safian,RD
通讯作者：
Safian,RD