Effects of experimental heart failure on atrial cellular and ionic electrophysiology
Effects of experimental heart failure on atrial cellular and ionic electrophysiology
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DOI：
10.1161/01.cir.101.22.2631
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发表时间：
2000-06-06
期刊：
影响因子：
37.8
通讯作者：
Nattel, S
中科院分区：
文献类型：
--
作者：
Li, DS;Melnyk, P;Nattel, S
背景-充血性心力衰竭（CHF）经常与心房颤动（AF）相关，但CHF对心房细胞电生理学的影响知之甚少。方法和结果-我们研究了心室起搏（220 - 240 bpm）5周诱发CHF犬心房肌细胞的动作电位（AP）特性和离子电流。CHF犬的心房肌细胞肥大（平均+/-SEM电容，89+/-2 pF，对照组为71+/-2 pF，每组n=160个细胞，P
Background-Congestive heart failure (CHF) is frequently associated with atrial fibrillation (AF), but little is known about the effects of CHF on atrial cellular electrophysiology.Methods and Results-We studied action potential (AP) properties and ionic currents in atrial myocytes from dogs with CHF induced by ventricular pacing at 220 to 240 bpm for 5 weeks. Atrial myocytes from CHF dogs were hypertrophied (mean+/-SEM capacitance, 89+/-2 pF versus 71+/-2 pF in control, n=160 cells per group, P