Oncogenic long noncoding RNA FAL1 in human cancer.
Oncogenic long noncoding RNA FAL1 in human cancer.
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人类癌症中的致癌长链非编码 RNA FAL1。
DOI：
10.4161/23723556.2014.977154
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发表时间：
2015-04
影响因子：
2.1
通讯作者：
Zhang L
中科院分区：
文献类型：
--
作者：
Zhong X;Hu X;Zhang L
长链非编码RNA（lncRNA）是指长度超过200个核苷酸的RNA转录物，它们似乎不具有蛋白质编码潜力。越来越多的证据表明lncRNA参与肿瘤的发生。我们的工作揭示了lncRNA β 1（1号染色体上的局灶性扩增lncRNA）在人类癌症中经常局灶性扩增并介导致癌功能。
Long non-coding RNAs (lncRNAs) are defined as RNA transcripts larger than 200 nucleotides that do not appear to have protein-coding potential. Accumulating evidence indicates that lncRNAs are involved in tumorigenesis. Our work reveals that lncRNA FAL1 (focally amplified lncRNA on chromosome 1) is frequently and focally amplified in human cancers and mediates oncogenic functions.