J-refocused coherence transfer spectroscopic imaging at 7 T in human brain.

J-refocused coherence transfer spectroscopic imaging at 7 T in human brain.
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DOI:
10.1002/mrm.22534
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发表时间:
2010-11
影响因子:
3.3
通讯作者:
Hetherington, H. P.
Hetherington, H. P.
中科院分区:
医学3区
文献类型:
--
作者:
Pan, J. W.;Avdievich, N.;Hetherington, H. P.

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短回波光谱通常用于最小化由于脑氨基酸的J-演变引起的信号调制。然而,短回波采集受到对大分子的高灵敏度的影响,这使得精确的基线确定变得困难。在这份报告中,我们描述了在回波时间(TE)为34毫秒的双回波J-重聚焦相干转移序列在7 T的实施,以尽量减少J-氨基酸的调制,同时也减少干扰大分子信号。在7 T的脉冲序列的模拟显示了谷氨酸,谷氨酰胺和N-乙酰天冬氨酸的优良分辨率。使用具有射频(RF)匀场的收发器阵列实现了在7 T下双回波采集的B1充足性。使用交替的RF分布来最小化收发器中的接收器相位抵消,通过快速单扫描校准来实现相干传输的精确相位确定。该方法在光谱成像模式下得到证实,其中n = 5名健康志愿者的代谢物值与文献和癫痫患者的代谢物值一致。
Short echo spectroscopy is commonly used to minimize signal modulation due to J-evolution of the cerebral amino acids. However, short echo acquisitions suffer from high sensitivity to macromolecules which make accurate baseline determination difficult. In this report, we describe implementation at 7 T of a double echo J-refocused coherence transfer sequence at echo time (TE) of 34 msec to minimize J-modulation of amino acids while also decreasing interfering macromolecule signals. Simulation of the pulse sequence at 7 T shows excellent resolution of glutamate, glutamine, and N-acetyl aspartate. B1 sufficiency at 7 T for the double echo acquisition is achieved using a transceiver array with radiofrequency (RF) shimming. Using an alternate RF distribution to minimize receiver phase cancellation in the transceiver, accurate phase determination for the coherence transfer is achieved with rapid single scan calibration. This method is demonstrated in spectroscopic imaging mode with n = 5 healthy volunteers resulting in metabolite values consistent with literature and in a patient with epilepsy.
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