Outcome from a prospective, longitudinal study of prenatal cocaine use: Preschool development at 3 years of age
Outcome from a prospective, longitudinal study of prenatal cocaine use: Preschool development at 3 years of age
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DOI：
10.1093/jpepsy/jsj027
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发表时间：
2006-01-01
影响因子：
3.6
通讯作者：
Wobie, K
中科院分区：
文献类型：
--
作者：
Behnke, M;Eyler, FD;Wobie, K
目的探讨产前可卡因暴露对儿童发育的影响。方法这项前瞻性、纵向研究招募了154名怀孕的可卡因使用者，她们在种族、胎次、社会经济地位和围产期风险方面与154名非可卡因使用者相匹配。用药情况由母体病史和尿液筛查确定。在3岁时，由一名对母亲用药史不知情的评估员对儿童受试者进行评估。在3岁家访期间，对照顾者、家庭和家庭进行了评估。结果结构方程模型显示，产前可卡因暴露量对调整后的出生头围有直接影响，而头围又直接影响幼儿发育。结论：我们不能证明产前可卡因暴露对学龄前发育的直接影响，这一结果与早期工作一致，现在将研究结果扩展到3岁。然而，可卡因通过其对出生时头围的直接影响继续对发育产生间接影响。
Objective To determine the effects of prenatal cocaine exposure on child development. Methods This prospective, longitudinal study recruited 154 pregnant cocaine users who were matched on race, parity, socioeconomic status, and perinatal risk to 154 noncocaine users. Drug use status was determined by maternal history and urine screening. At 3 years of age, the child subjects were assessed by an evaluator blinded to maternal drug use history. During a home visit at age 3, caregiver, family, and home assessments were administered. Results Structural equation modeling showed a direct effect of the amount of prenatal cocaine exposure on the adjusted birth head circumference which in turn directly affected preschool development. Conclusions We could not demonstrate a direct effect of prenatal cocaine exposure on preschool development, a result that is consistent with that of earlier work and now extending findings to age 3. However, cocaine continued to exert an indirect effect on development through its direct effect on the head circumference at birth.