Identification and location of brain protein 4.1.
Identification and location of brain protein 4.1.
复制标题
脑蛋白的鉴定和定位 4.1。
DOI：
10.1126/science.6374897
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Zagon,IS
中科院分区：
文献类型：
--
作者：
Goodman,SR;Casoria,LA;Coleman,DB;Zagon,IS
蛋白4.1是一种膜骨架蛋白，其将血影蛋白和肌动蛋白之间的低亲和力相互作用转化为血影蛋白、蛋白4.1和肌动蛋白的高亲和力三元复合物，这对红细胞的结构稳定性至关重要。猪脑中含有一个87千道尔顿的蛋白4.1的免疫反应类似物，它与猪红细胞蛋白4.1具有部分序列同源性，并且与小脑神经元和神经胶质细胞类型的皮质细胞质中的血影蛋白具有相同的位置。
Protein 4.1 is a membrane skeletal protein that converts the low-affinity interaction between spectrin and actin into a high-affinity ternary complex of spectrin, protein 4.1, and actin that is essential to the structural stability of the erythrocyte. Pig brain was shown to contain an 87-kilodalton immunoreactive analog of protein 4.1 that has partial sequence homology with pig erythrocyte protein 4.1 and the same location as spectrin in the cortical cytoplasm of neuronal and glial cell types of the cerebellum.