Maintenance of self-tolerance by apoptotic cell clearance.
Maintenance of self-tolerance by apoptotic cell clearance.
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DOI：
10.2741/3135
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发表时间：
2008-05
期刊：
影响因子：
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通讯作者：
Masato Tanaka;Yasunobu Miyake;K. Asano
中科院分区：
文献类型：
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作者：
Masato Tanaka;Yasunobu Miyake;K. Asano
先天免疫细胞在遗传上被赋予了识别“非自身”微生物的能力，并诱导适当的免疫反应来消灭它们。另一方面，免疫细胞必须识别自身细胞，以避免攻击正常组织。为此，免疫细胞利用自体细胞尸体。当细胞发生凋亡时，细胞尸体迅速被吞噬细胞吞噬，如巨噬细胞和树突状细胞。这些吞噬细胞呈递来自死亡细胞尸体的自身抗原来诱导耐受。凋亡细胞清除障碍常导致自身免疫性疾病。静脉注射死细胞尸体可以诱导对细胞相关抗原的耐受性，这种策略在治疗人类各种自身免疫性和炎症性疾病中具有潜在的应用前景。注射的死细胞尸体被脾脏边缘区（MZ）的吞噬细胞迅速清除。在这些吞噬细胞中，巨噬细胞在快速清除死亡细胞尸体以及随后诱导对细胞相关抗原的耐受方面发挥着关键作用。
Innate immune cells are genetically conferred the ability to recognize microorganisms as "non-self", and to induce appropriate immune responses to eliminate them. On the other hand, immune cells should recognize self cells in order to avoid attacking normal tissues. For this purpose, immune cells make use of self-cell corpses. When cells undergo apoptosis, cell corpses are rapidly phagocytosed by phagocytes, such as macrophages and dendritic cells. These phagocytes present self antigens derived from dead cell corpses to induce tolerance. Impairment of apoptotic cell clearance often results in autoimmune disorder. Intravenous injection of dead cell corpses can induce tolerance to cell-associated antigens, and this strategy has potential use in the treatment of various autoimmune and inflammatory disorders in human. Injected dead cell corpses are rapidly cleared by phagocytes located in the marginal zone (MZ) of spleen. Among those phagocytes, macrophages play a critical role in the rapid clearance of dead cell corpses, and the subsequent induction of tolerance to cell-associated antigens.