Polyspecific, antiviral immune response distinguishes multiple sclerosis and neuromyelitis optica
Polyspecific, antiviral immune response distinguishes multiple sclerosis and neuromyelitis optica
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DOI：
10.1136/jnnp.2007.133330
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发表时间：
2008-10-01
影响因子：
11
通讯作者：
Voltz, R.
中科院分区：
文献类型：
--
作者：
Jarius, S.;Franciotta, D.;Voltz, R.
背景资料：多发性硬化症（MS）患者中80-100%存在针对嗜神经病毒如麻疹、风疹和水痘带状疱疹病毒（MRZ反应，MRZR）的多特异性鞘内体液免疫应答，但迄今为止尚未在视神经肌萎缩症（NMO）患者中进行评估。结果：42例MS患者中有37例出现MRZ阳性反应，即至少两种阳性AI同时出现，而20例NMO患者中仅有1例出现MRZ阳性反应（P < 0.0001）。中位AI值组间差异显着（p < 0.0005）。结论：多发性硬化症的多特异性抗病毒体液免疫反应的特点是广泛失踪的NMO，无论NMO-IgG状态的患者。我们的研究结果进一步强化了NMO在病理学上与MS不同的理由。
Background: A polyspecific, intrathecal humoral immune response against neurotropic viruses such as measles, rubella and varicella zoster virus (MRZ reaction, MRZR) is present in 80-100% of patients with multiple sclerosis (MS), but has not to date been evaluated in patients with neuromyelitis optica (NMO).Aims: To evaluate whether MRZR distinguishes NMO and MS.Methods: 20 patients with NMO and 42 with MS were included. The intrathecal synthesis of antibodies against measles, rubella and varicella zoster virus was detected by calculation of the respective antibody indices (AI).Results: A positive MRZ reaction, as defined by a combination of at least two positive AIs, was found in 37/42 MS, but in only 1/20 NMO patients (p < 0.0001). Median AI values differed significantly between the groups (p < 0.0005).Conclusions: The polyspecific antiviral humoral immune response characteristic for MS is widely missing in NMO, irrespective of the NMO-IgG status of the patients. Our findings further strengthen the case for NMO being pathologically distinct from MS.