Thyroid Disease and the Cardiovascular System
Thyroid Disease and the Cardiovascular System
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DOI：
10.1016/j.ecl.2014.02.005
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发表时间：
2014-06-01
影响因子：
4.5
通讯作者：
Klein, Irwin
中科院分区：
文献类型：
--
作者：
Danzi, Sara;Klein, Irwin
甲状腺激素，特别是三碘甲状腺原氨酸（T-3），对心脏和心血管系统有显着影响。甲状腺功能减退症、甲状腺功能亢进症、亚临床甲状腺疾病和低T-3综合征均通过对心肌细胞和血管平滑肌细胞的基因组和非基因组效应引起心脏和心血管异常。在健康受损的情况下，如发生在心脏病中，甲状腺激素代谢的改变可能进一步损害心脏和心血管功能。心脏病的诊断和治疗可能受益于甲状腺激素状态的分析，包括血清总T-3水平。
Thyroid hormones, specifically triiodothyronine (T-3), have significant effects on the heart and cardiovascular system. Hypothyroidism, hyperthyroidism, subclinical thyroid disease, and low T-3 syndrome each cause cardiac and cardiovascular abnormalities through both genomic and non-genomic effects on cardiac myocytes and vascular smooth muscle cells. In compromised health, such as occurs in heart disease, alterations in thyroid hormone metabolism may further impair cardiac and cardiovascular function. Diagnosis and treatment of cardiac disease may benefit from including analysis of thyroid hormone status, including serum total T-3 levels.