Positive Association between Plasma Amylin and Cognition in a Homebound Elderly Population
Positive Association between Plasma Amylin and Cognition in a Homebound Elderly Population
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DOI：
10.3233/jad-140210
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发表时间：
2014-01-01
影响因子：
4
通讯作者：
Stern, Robert A.
中科院分区：
文献类型：
--
作者：
Qiu, Wei Qiao;Au, Rhoda;Stern, Robert A.
我们最近的研究报告说，胰淀素，胰腺肽，很容易穿过血脑屏障，提高学习和记忆在阿尔茨海默氏症小鼠模型。然而，外周胰淀素和人类认知之间的关系尚不清楚。在这项随访研究中，使用横断面、居家老年人群，通过与言语记忆（p = 0.0002）和视觉构建任务（p = 0.004）的正相关性以及与注意力（p < 0.0001）和执行功能（p = 0.04）的定时测量的负相关性，表明随着血浆胰淀素四分位数的增加，认知功能得到改善。在调整人口统计学信息、载脂蛋白E4等位基因、糖尿病、中风、肾功能和血脂谱后，血浆胰淀素的log（10）仍然与这些认知领域相关。相比之下，血浆淀粉样蛋白β肽与这些特定的认知领域无关。我们的研究表明，外周胰淀素可能对认知能力下降有保护作用，特别是在受阿尔茨海默病影响的领域。
Our recent study reported that amylin, a pancreatic peptide that readily crosses the blood-brain barrier, improves learning and memory in Alzheimer's disease mouse models. However, the relationship between peripheral amylin and cognition in humans is unknown. In this follow-up study, using a cross-sectional, homebound elderly population, improvement in cognitive function with increasing quartiles of plasma amylin was suggested by positive association with verbal memory (p = 0.0002) and visuoconstruction tasks (p = 0.004), and inverse association with timed measures of attention (p < 0.0001) and executive function (p = 0.04). After adjusting for demographic information, apolipoprotein E4 allele, diabetes, stroke, kidney function, and lipid profile, log(10) of plasma amylin remained associated with these cognitive domains. In contrast, plasma amyloid-beta peptide was not associated with these specific cognitive domains. Our study suggests that peripheral amylin may be protective for cognitive decline, especially in the domains affected by Alzheimer's disease.