Decreased Cerebral Blood Flow in Mesial Thalamus and Precuneus/PCC during Midazolam Induced Sedation Assessed with ASL
Decreased Cerebral Blood Flow in Mesial Thalamus and Precuneus/PCC during Midazolam Induced Sedation Assessed with ASL
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通过 ASL 评估咪达唑仑诱导镇静期间内侧丘脑和楔前叶/PCC 脑血流量减少
DOI：
10.1007/s12021-018-9368-y
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发表时间：
2018-10-01
期刊：
影响因子：
3
通讯作者：
Li, Kuncheng
中科院分区：
文献类型：
--
作者：
Liang, Peipeng;Xu, Yachao;Li, Kuncheng
虽然先前的一些研究表明咪达唑仑诱导的轻度镇静是由静息状态网络的功能断开引起的，但对与其作用相关的脑血流量（CBF）的潜在改变知之甚少。采用随机、双盲、受试者内交叉设计，同时对12名健康年轻志愿者在注射生理盐水或咪达唑仑前后进行动脉自旋标记（ASL）灌注MRI扫描。咪达唑仑给药前后的MRI信号对比显示，双侧丘脑中内侧和楔前叶/后扣带皮层（PCC） CBF减少。在控制了注射和头部运动的影响后，这些效果得到了证实。这些发现为咪达唑仑诱导的轻度镇静与皮层功能整合的破坏有关提供了新的证据，并对意识的神经基础产生了新的影响。
While some previous work suggests that midazolam-induced light sedation results from the functional disconnection within resting state network, little is known about the underlying alterations of cerebral blood flow (CBF) associated with its effects. A randomized, double-blind, within-subject, cross-over design was adopted, while 12 healthy young volunteers were scanned with arterial spin-labeling (ASL) perfusion MRI both before and after an injection of either saline or midazolam. The contrast of MRI signal before and after midazolam administration revealed the CBF decrease in the bilateral mesial thalamus and precuneus/posterior cingulate cortex (PCC). These effects were confirmed after controlling for any effect of injection as well as head motions. These findings provide new evidences that midazolam-induced light sedation is related to the disruption of cortical functional integration, and have new implications to the neural basis of consciousness.