Therapeutic Cancer Vaccines.
Therapeutic Cancer Vaccines.
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DOI：
10.1007/978-94-017-7555-7_3
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发表时间：
2016
影响因子：
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通讯作者：
Zhen-long Ye;Zhong Li;Hua-jun Jin;Q. Qian
中科院分区：
文献类型：
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作者：
Zhen-long Ye;Zhong Li;Hua-jun Jin;Q. Qian
癌症是导致死亡的主要疾病之一。预防和治疗肿瘤是降低肿瘤发生率、延长患者生命的重要途径。肿瘤免疫治疗在经历了基础和临床研究的多次失败后，其颠覆性的研究成果备受关注。基于对肿瘤抗原的基因组学和蛋白质组学的深入分析，多种靶向肿瘤抗原的癌症疫苗已经在临床前和人体临床试验中进行了测试。许多治疗性肿瘤疫苗单独使用或与其他常规肿瘤治疗方法联合使用均取得了显著的疗效，显示出巨大的临床应用潜力。随着肿瘤免疫调节机制的阐明，有效、可控、持久的肿瘤疫苗将在肿瘤治疗、延长生存期、预防复发等方面发挥重要作用。本章主要综述了肿瘤疫苗研究和临床应用的最新进展和动态，探讨肿瘤疫苗研究中存在的障碍，促进肿瘤疫苗的有效性。
Cancer is one of the major leading death causes of diseases. Prevention and treatment of cancer is an important way to decrease the incidence of tumorigenesis and prolong patients’ lives. Subversive achievements on cancer immunotherapy have recently been paid much attention after many failures in basic and clinical researches. Based on deep analysis of genomics and proteomics of tumor antigens, a variety of cancer vaccines targeting tumor antigens have been tested in preclinical and human clinical trials. Many therapeutic cancer vaccines alone or combination with other conventional treatments for cancer obtained spectacular efficacy, indicating the tremendously potential application in clinic. With the illustration of underlying mechanisms of cancer immune regulation, valid, controllable, and persistent cancer vaccines will play important roles in cancer treatment, survival extension and relapse and cancer prevention. This chapter mainly summarizes the recent progresses and developments on cancer vaccine research and clinical application, thus exploring the existing obstacles in cancer vaccine research and promoting the efficacy of cancer vaccine.